The aim of this study was to investigate the contributions of multiple transport mechanisms to
the intestinal absorption of metformin, focusing on OCT3, PMAT, THTR2, SERT and OCTN2 …

Oral bioavailability (F) is determined as fraction of the drug dose absorbed through the
gastrointestinal membranes (Fa), the unmetabolized fraction of the absorbed dose that …

As a functional membrane protein, drug transporters play an important role in the absorption,
distribution, metabolism and excretion of drugs. The functional omission or inhibition of drug …

The involvement of intestinal permeability in the oral absorption of clarithromycin (CAM), a
macrolide antibiotic, and telithromycin (TEL), a ketolide antibiotic, in the presence of efflux …

Methotrexate (MTX) and cyclosporine (CyA) are coadministered in a number of diseases. In
this study, the effects of CyA on the hepatobiliary disposition of MTX were investigated in an …

A vast number of drugs are subjected to active or facilitated transport and multiple transport
mechanism may contribute to the net flux during drug absorption. The main objective of this …

A simple, specific and sensitive reversed-phase high performance liquid chromatographic
(RP-HPLC) method with UV absorbance detection was developed and validated for …

Intestinal passive transport of several hydrophilic drugs (and probe compounds) was
examined in the large intestine (colon), in comparison with that in the small intestine, in an …

Methotrexate (MTX) is used not only for the cancer chemotherapy but also for the treatment
of rheumatic disease, often together with non-steroidal anti-inflammatory drugs (NSAIDs) …

抄録 The intestinal transport mechanism of 5-fluorouracil (5-FU) was investigated in the
intestinal everted sacs and brush border membrane vesicles (BBMVs) of rats. In the everted …