Abstract Cyclooxygenase-2 (COX-2), the enzyme that converts arachidonic acid to
prostaglandins, is overexpressed in a variety of different tumors, including those of the colon …

Recently, we demonstrated that elevated expression of cyclooxygenase 2 (COX-2) is
frequently seen in a specific type of lung cancer, ie, adenocarcinoma, and is possibly …

BACKGROUND Cyclooxygenase (Cox) is the main target enzyme for the nonsteroidal
antiinflammatory drugs that have been shown to suppress carcinogenesis in both …

Abstract Cyclooxygenase (COX)-2 expression was immunohistochemically examined in 59
human lung cancers as well as in normal and premalignant lung specimens. In contrast to …

Preclinical studies suggest that cyclooxygenase (COX)-2 may be involved in the molecular
pathogenesis of some types of lung cancer. Most of the available studies point to its …

Both cyclooxygenase (COX)-2 and epidermal growth factor receptor (EGFR) are thought to
play important roles in the pathogenesis of non-small cell lung cancer (NSCLC). A number …

Lung cancer is by far the leading cause of cancer-related death. Overall survival is poor and
has not improved substantially over the last half century. It is clear that new approaches are …

Objective To investigate cyclooxygenase-2 (COX-2) mRNA expression in curatively resected
non-small cell lung cancer (NSCLC) and to determine its association with prognosis …

A low incidence of lung carcinoma has been reported in cases of prolonged use of aspirin.
Cyclooxygenase (COX) 2 expression is frequently seen in adenocarcinoma of the lung, but …

BACKGROUND The cyclooxygenase (COX) enzyme catalyzes the formation of
prostaglandins, which can affect cell proliferation and alter the response of the immune …