The repair of large bone defects remains a major clinical orthopaedic challenge. Bone is a
highly vascularised tissue reliant on the close spatial and temporal connection between …

Inadequate vascularization of engineered tissue constructs is a main challenge in
developing a clinically impactful therapy for large, complex, and recalcitrant bone defects. It …

Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New
blood vessel formation is crucial during both primary bone development as well as fracture …

Bone has the unique capacity to heal without the formation of a fibrous scar, likely because
several of the cellular and molecular processes governing bone healing recapitulate the …

Poor angiogenesis within tissue‐engineered grafts has been identified as a main challenge
limiting the clinical introduction of bone tissue‐engineering (BTE) approaches for the repair …

Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

Bone regeneration has long been a major focus for tissue engineers and the importance of
vascularization to the bone regeneration process has been well documented. Over the past …

The regeneration of bone in segmental defects has historically been a challenge in the
orthopedic field. In particular, a lack of vascular supply often leads to nonunion and …

The lack of a functional vascular supply has, to a large extent, hampered the whole range of
clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …

This review focuses on current tissue engineering strategies for promoting vascularized
bone regeneration. We review the role of angiogenic growth factors in promoting …