The present invention provides genetically modi? ed animals and cells comprising edited
chromosomal sequences encod ing proteins that are associated With neurotransmission dis …

US9394531B2 - Compositions for linking DNA-binding domains and cleavage domains -
Google Patents US9394531B2 - Compositions for linking DNA-binding domains and …

Jasin,“Genetic manipulation of genomes with rare-cutting endonucleases.” Trends in Genet.,
12: 224-228, 1996. Liu et al.,“Validated zinc finger protein designs for all 16 GNN DNA triplet …

The invention relates to methods for targeting an exogenous polynucleotide or exogenous
complementary polynucle otide pair to a predetermined endogenous DNA target sequence …

Compositions and methods concern the sequence modifica tion of an endogenous genomic
DNA region. Certain aspects relate to a method for site-specific sequence modification of a …

Compositions and methods for modifying genomic DNA sequences are provided. The
methods produce double-stranded breaks (DSBs) at pre-determined target sites in a …

2018-04-16 Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
reassignment THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ASSIGNMENT OF …

0.003 Understanding the biological function of mamma lian genes remains one of the major
challenges in the post genomic era. With the human genome Sequenced, less than 20% of …

The present invention provides compositions and improved methods for multi-site directed
mutagenesis and DNA shuf fling. The present compositions and methods provide increased …

US8716479B2 - Methods for stereoselective reduction - Google Patents US8716479B2 -
Methods for stereoselective reduction - Google Patents Methods for stereoselective reduction …