During antiviral defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-
phosphorylated STAT1 (PY-STAT1), which occurs via a subset of karyopherin alpha (KPNA) …

Ebola virus (EBOV) infection blocks cellular production of alpha/beta interferon (IFN-α/β) and
the ability of cells to respond to IFN-α/β or IFN-γ. The EBOV VP35 protein has previously …

Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are
characterized by early suppression of the host innate immune system. One of the proteins …

The Ebolavirus VP24 protein counteracts alpha/beta interferon (IFN-α/β) and IFN-γ signaling
by blocking the nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1) …

The Zaire ebolavirus protein VP24 was previously demonstrated to inhibit alpha/beta
interferon (IFN-α/β)-and IFN-γ-induced nuclear accumulation of tyrosine-phosphorylated …

Ebola virus causes devastating hemorrhagic fever outbreaks for which no approved
therapeutic exists. The viral nucleocapsid, which is minimally composed of the proteins NP …

Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite
considerable efforts, no essential cellular receptors for filovirus entry have been identified …

Ebola hemorrhagic fever is a rapidly progressing acute febrile illness characterized by high
virus replication, severe immunosuppression, and case fatalities of ca. 80%. Inhibition of …

Work with infectious Ebola viruses is restricted to biosafety level 4 (BSL4) laboratories,
presenting a significant barrier for studying these viruses. Life cycle modeling systems …

The highly virulent nature of Ebola virus, evident from the 2014 West African pandemic,
highlights the need to develop vaccines or therapeutic agents that limit the pathogenesis …