The central dogma of mammalian brain sexual differentiation has contended that sex
steroids of gonadal origin organize the neural circuits of the developing brain [1]. Recent …

Sexual differentiation of the brain is thought to be regulated by hormonal signals from the
developing male gonad. However, more-recent experimental and clinical data throw some …

Transient activation of the gene Sry in the gonadal ridge during a brief period of embryonic
development is believed to function as a key signal for sex determination. However, a …

J. Neurochem.(2012) 122, 260–271. Abstract The male gender is determined by the sex‐
determining region on the Y chromosome (SRY) transcription factor. The unexpected action …

The dominant theory of sexual differentiation of the brain holds that sex differences in brain
anatomy and function arise because of the action of gonadal steroids during embryonic and …

The prevalence, age of onset, pathophysiology, and symptomatology of many neurological
and neuropsychiatric conditions differ significantly between males and females. Females …

Sex differences in the brain are caused by differences in gonadal secretions: higher levels of
testosterone during fetal and neonatal life cause the male brain to develop differently than …

The Y chromosomal gene Sry encodes a putative transcription factor which appears to serve
as a master switch initiating testicular development. Here we show that this gene is …

In mammals, sex is determined by the Y chromosome, which encodes a testis-determining
factor (TDF). This factor causes the undifferentiated embryonic gonads to develop as testes …

This review summarizes current knowledge of the genetic and hormonal control of sexual
differentiation of the reproductive system, brain and brain function. While the chromosomal …