Patients with hypomorphic mutations in STAT3 and patients with hypermorphic mutations in
STAT1 share several clinical and cellular phenotypes suggesting overlapping …

The STAT3 signaling pathway is required for early Th17 cell development, and therapies
targeting this pathway are used for autoimmune disease. However, the role of STAT3 in …

Mutations in STAT3 have recently been shown to cause autoimmune diseases through
increased lymphoproliferation. We describe a novel Pro471Arg STAT3 mutation in a patient …

Abstract Gain-of-function (GOF) mutations in the gene for signal transducer and activator of
transcription 1 (STAT1) account for approximately one-half of patients with chronic …

STAT3 activation has been observed in several autoimmune diseases, suggesting that
STAT3-mediated pathways promote pathologic immune responses. We provide in vivo …

Th cell subsets develop in response to multiple activating signals, including the cytokine
environment. IL-9–secreting T cells develop in response to the combination of IL-4 and TGF …

The transcription factor STAT3 is critically required for the differentiation of Th17 cells, a T
cell subset involved in various chronic inflammatory diseases. In this article, we report that …

The transcription factors STAT 3 and STAT 4 are essential for lymphocyte differentiation and
function. Interleukin (IL)‐17 producing γδ T (γδT17) cells are innate lymphocytes important …

Naive CD4+ T cells differentiate into specific effector subsets—Th1, Th2, Th17, and T
follicular helper (Tfh)—that provide immunity against pathogen infection. The signaling …

TH17 differentiation is critically controlled by “signal 3” of cytokines (IL-6/IL-23) through
STAT3. However, cytokines alone induced only a moderate level of STAT3 phosphorylation …