ROS-responsive nanoparticles targeting inflamed colon for synergistic therapy of inflammatory bowel disease via barrier repair and anti-inflammation
D Wang, Q Jiang, R Shen, L Peng, W Zhou, T Meng… - Nano Research, 2024 - Springer
The destruction of the intestinal barrier is likely to cause an increase in intestinal
permeability and cause pathological damage. Numerous studies have demonstrated that …
permeability and cause pathological damage. Numerous studies have demonstrated that …
ROS Scavenging and inflammation-directed polydopamine nanoparticles regulate gut immunity and flora therapy in inflammatory bowel disease
M Bao, K Wang, J Li, Y Li, H Zhu, M Lu, Y Zhang… - Acta Biomaterialia, 2023 - Elsevier
Dysfunction of the intestinal mucosal immune system and dysbiosis of the intestinal
microflora can induce inflammatory bowel disease. However, drug-mediated clinical …
microflora can induce inflammatory bowel disease. However, drug-mediated clinical …
[HTML][HTML] Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine
T Sun, CHT Kwong, C Gao, J Wei, L Yue, J Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Ulcerative colitis (UC) is featured with relapsing inflammation in the colon, where
macrophages are recruited and polarized locally into M1 type to drive further inflammation …
macrophages are recruited and polarized locally into M1 type to drive further inflammation …
“Two-birds-one-stone” colon-targeted nanomedicine treats ulcerative colitis via remodeling immune microenvironment and anti-fibrosis
J Zhang, A Ou, X Tang, R Wang, Y Fan, Y Fang… - Journal of …, 2022 - Springer
Dysregulated mucosal immune responses and colonic fibrosis impose two formidable
challenges for ulcerative colitis treatment. It indicates that monotherapy could not sufficiently …
challenges for ulcerative colitis treatment. It indicates that monotherapy could not sufficiently …
[HTML][HTML] Reactive oxygen species-responsive nanocarrier ameliorates murine colitis by intervening colonic innate and adaptive immune responses
Ulcerative colitis (UC) is a chronic or relapsing inflammatory disease with limited therapeutic
outcomes. Pterostilbene (PSB) is a polyphenol-based anti-oxidant that has received …
outcomes. Pterostilbene (PSB) is a polyphenol-based anti-oxidant that has received …
Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances
S Hu, R Zhao, Y Xu, Z Gu, B Zhu, J Hu - Journal of Materials Chemistry …, 2024 - pubs.rsc.org
Inflammatory bowel disease (IBD) is a chronic and idiopathic condition that results in
inflammation of the gastrointestinal tract, leading to conditions such as ulcerative colitis and …
inflammation of the gastrointestinal tract, leading to conditions such as ulcerative colitis and …
pH and reactive oxygen species‐sequential responsive nano‐in‐micro composite for targeted therapy of inflammatory bowel disease
S Bertoni, Z Liu, A Correia, JP Martins… - Advanced functional …, 2018 - Wiley Online Library
Oxidative stress and abnormally high levels of reactive oxygen species (ROS) play an
essential role in the pathogenesis and progression of inflammatory bowel disease (IBD) …
essential role in the pathogenesis and progression of inflammatory bowel disease (IBD) …
Multistage-responsive nanocomplexes attenuate ulcerative colitis by improving the accumulation and distribution of oral nucleic acid drugs in the colon
X Li, Y Yang, Z Wang, H Ju, X Fu, L Zou… - … Applied Materials & …, 2022 - ACS Publications
Oral gene therapy has emerged as a potential optimal treatment for ulcerative colitis (UC).
Nucleic acid drugs possessing versatility can not only inhibit inflammation but realize colon …
Nucleic acid drugs possessing versatility can not only inhibit inflammation but realize colon …
Dual-Sensitive Carbohydrate-Based Nanosystem for Targeted Drug Delivery to Potentiate the Therapeutic Efficacy of Ulcerative Colitis
Y Wang, X Song, R Cui, X Luo, J Dong… - International Journal …, 2024 - Taylor & Francis
Purpose Conventional oral formulations for inflammatory bowel disease (IBD) treatment are
less than satisfactory, due to the poor controllability of drug release and lack of specificity to …
less than satisfactory, due to the poor controllability of drug release and lack of specificity to …
Orally administrated inflamed colon-targeted nanotherapeutics for inflammatory bowel disease treatment by oxidative stress level modulation in colitis
Inflammatory bowel disease (IBD) is characterized by an inappropriate and persistent
inflammatory immune response and is often accompanied by excessive reactive oxygen …
inflammatory immune response and is often accompanied by excessive reactive oxygen …
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