Many tumors show a mutant or inactive tumor suppressor p53 (TP53) status, and TP53 in the
tumor-carrying human papillomavirus (HPV) may be dysfunctional because of inhibition by …

In order to gain a better understanding of the role of p53 in radiation-induced mitotic failure,
apoptosis and mutagenesis, we introduced the HPV16 E6 gene via a retroviral vector into …

Suppression of wild-type p53 expression has been shown to enhance the radiation
resistance of human diploid fibroblasts, but results concerning the role of p53 expression in …

The molecular basis of tumor response to therapeutic radiation is poorly understood. Recent
evidence suggests the p53 tumor suppressor gene may be involved in production of the G1 …

In order to examine the role of p53 expression on the sensitivity of cells to radiation-induced
reproductive failure, we examined the radiosensitivity of a human diploid fibroblast cell strain …

The p53 tumour suppressor gene is activated following cellular exposure to DNA‐damaging
agents. The functions of wild‐type p53 protein include transient blocking of cell cycle …

Mutations in the p53 tumor suppressor gene have been found in more than 50% of human
tumors including those in breast, colon, lung, and oral cavity. However, the significance of …

Purpose: The tumour suppressor protein p53 is considered to have an impact on the
radiosensitivity of tumour cells. However, this concept does not easily translate to the tumour …

Loss of p53 function has been shown to cause increased resistance to ionizing radiation in
normal murine cells; however, the role of p53 in radioresistance of human tumor cells is less …

BACKGROUND: Activation of the transcription factor NF-κB is part of the immediate early
response of tissues to ionizing irradiation. This pathway has been shown to protect cells …