Bone disorders are of significant concern due to increase in the median age of our
population. Traditionally, bone grafts have been used to restore damaged bone. Synthetic …

Bone tissue has the capability to regenerate itself; however, defects of a critical size prevent
the bone from regenerating and require additional support. To aid regeneration, bone …

The management of bone defects is complicated by the presence of clinical conditions, such
as critical-sized defects created by high-energy trauma, tumour resection, infection, and …

Bone tissue engineering has been continuously developing since the concept of “tissue
engineering” has been proposed. Biomaterials that are used as the basic material for the …

Large injuries to bones are still one of the most challenging musculoskeletal problems.
Tissue engineering can combine stem cells, scaffold biomaterials, and biofactors to aid in …

The worldwide incidence of bone disorders and conditions has trended steeply upward and
is expected to double by 2020, especially in populations where aging is coupled with …

The use of bone grafts is the standard to treat skeletal fractures, or to replace and regenerate
lost bone, as demonstrated by the large number of bone graft procedures performed …

Bone repair and regeneration is a dynamic process that involves a complex interplay
between the (1) ground substance,(2) cells, and (3) milieu. While each constituent is integral …

In clinical terms, bone grafting currently involves the application of autogenous, allogeneic,
or xenogeneic bone grafts, as well as natural or artificially synthesized materials, such as …

The goal of a biomaterial is to support the bone tissue regeneration process at the defect site
and eventually degrade in situ and get replaced with the newly generated bone tissue …