Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer
TC Walser, S Rifat, X Ma, N Kundu, C Ward… - Cancer research, 2006 - AACR
Tumor cells aberrantly express chemokines and/or chemokine receptors, and some may
promote tumor growth and metastasis. We examined the expression and function of …
promote tumor growth and metastasis. We examined the expression and function of …
CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine model
X Ma, K Norsworthy, N Kundu, WH Rodgers… - Molecular cancer …, 2009 - AACR
Breast tumor cells express the chemokine receptor CXCR3, which binds the ligands CXCL9,
CXCL10, and CXCL11. CXCR3 and other chemokine receptors may mediate tumor …
CXCL10, and CXCL11. CXCR3 and other chemokine receptors may mediate tumor …
CXCR4 regulates growth of both primary and metastatic breast cancer
The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …
The significance of cancer cell expression of the chemokine receptor CXCR4
F Balkwill - Seminars in cancer biology, 2004 - Elsevier
Malignant cells from at least 23 different types of cancer express the chemokine receptor
CXCR4 and respond to its ligand CXCL12. This receptor ligand pair appears to be involved …
CXCR4 and respond to its ligand CXCL12. This receptor ligand pair appears to be involved …
Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells
T Murakami, W Maki, AR Cardones, H Fang, A Tun Kyi… - Cancer research, 2002 - AACR
The chemokine receptors CC chemokine receptor (CCR) 7 and CXC chemokine receptor
(CXCR) 4 have been implicated in cancer metastasis. To evaluate whether CXCR4 is …
(CXCR) 4 have been implicated in cancer metastasis. To evaluate whether CXCR4 is …
Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast …
Y Ueda, NF Neel, E Schutyser, D Raman, A Richmond - Cancer research, 2006 - AACR
The CXC chemokine receptor 4 (CXCR4) contributes to the metastasis of human breast
cancer cells. The CXCR4 COOH-terminal domain (CTD) seems to play a major role in …
cancer cells. The CXCR4 COOH-terminal domain (CTD) seems to play a major role in …
Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases
SY Kim, CH Lee, BV Midura, C Yeung… - Clinical & experimental …, 2008 - Springer
Metastasis continues to be the leading cause of mortality for patients with cancer. High
expression of the chemokine receptor CXCR4 correlates with poor prognosis in many …
expression of the chemokine receptor CXCR4 correlates with poor prognosis in many …
The expression of the chemokine receptor CXCR3 and its ligand, CXCL10, in human breast adenocarcinoma cell lines
L Goldberg-Bittman, E Neumark, O Sagi-Assif… - Immunology letters, 2004 - Elsevier
The acquisition of a metastatic phenotype in breast epithelial cells is a progressive process,
influenced by a large variety of cellular and soluble factors. Of these, members of the …
influenced by a large variety of cellular and soluble factors. Of these, members of the …
The CXCR5 chemokine receptor is expressed by carcinoma cells and promotes growth of colon carcinoma in the liver
J Meijer, IS Zeelenberg, B Sipos, E Roos - Cancer research, 2006 - AACR
The chemokine receptor CXCR5 is expressed by B cells and certain T cells and controls
their migration into and within lymph nodes. Its ligand BCA-1/CXCL13 is present in lymph …
their migration into and within lymph nodes. Its ligand BCA-1/CXCL13 is present in lymph …
Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes
K Kawada, H Hosogi, M Sonoshita, H Sakashita… - Oncogene, 2007 - nature.com
Chemokines and their receptors are essential for leukocyte trafficking, and also implicated in
cancer metastasis to specific organs. We have recently demonstrated that CXCR3 plays a …
cancer metastasis to specific organs. We have recently demonstrated that CXCR3 plays a …