PURPOSE: This study investigates the COX-2 expression in human primary breast
carcinomas and its relationship with both angiogenesis and the expression of estrogen …

Abstract Purpose: Cyclooxygenase (COX)-2 is overexpressed in breast cancer and may
have a role in regulating tumor growth via effects on angiogenesis, cell proliferation, or …

Background Cyclo-oxygenase (COX) is the rate-limiting enzyme in converting arachidonic
acid to prostaglandins. There are two isoforms of COX: COX-1, which is expressed in many …

Background: Cyclooxygenase-2 (COX-2) overexpression clearly plays an important role in
the pathogenesis of breast cancer. In this study, we analysed the relationship between COX …

Aims: Cyclo-oxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin
biosynthesis. COX-2 is induced by a wide variety of stimuli, and present during inflammation …

It seems certain that COX-2 is related to tumor and some data suggested that COX-2 might
have relation to tumor malignance and angiogenesis. In order to elucidate the relationship …

Purpose To determine whether COX-2 expression is associated with clinicopathological
parameters, including c-erb-B2 overexpression and angiogenesis, and the disease-free …

Aims: There is a growing body of evidence that cyclo-oxygenase 2 (COX-2) plays an
important role in carcinogenesis and angiogenesis of human tumours. The present study …

BACKGROUND Cyclooxygenases regulate the production of prostaglandins and play a role
in tumor development and progression. The authors investigated the prognostic impact of …

Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that converts arachidonic acid
to prostaglandins. Overexpression of the COX-2 gene in mammary glands of transgenic …