Fluorinated antimicrobial lysine‐based peptidomimetics with activity against methicillin‐resistant Staphylococcus pseudintermedius

N Molchanova, PR Hansen, P Damborg… - Journal of Peptide …, 2018 - Wiley Online Library
Staphylococcus pseudintermedius is the predominant opportunistic pathogen in dogs
causing primarily integumentary infections such as pyoderma and otitis. The worldwide …

Structure–Activity Study, Characterization, and Mechanism of Action of an Antimicrobial Peptoid D2 and Its d- and l-Peptide Analogues

I Greco, JE Hansen, B Jana, N Molchanova, A Oddo… - Molecules, 2019 - mdpi.com
Methicillin-resistant Staphylococcus pseudintermedius (MRSP) constitutes an emerging
health problem for companion animals in veterinary medicine. Therefore, discovery of novel …

Antibacterial Activity of Novel Cationic Peptides against Clinical Isolates of Multi-Drug Resistant Staphylococcus pseudintermedius from Infected Dogs

MF Mohamed, GK Hammac, L Guptill, MN Seleem - PloS one, 2014 - journals.plos.org
Staphylococcus pseudintermedius is a major cause of skin and soft tissue infections in
companion animals and has zoonotic potential. Additionally, methicillin-resistant S …

Non hemolytic short peptidomimetics as a new class of potent and broad-spectrum antimicrobial agents

RN Murugan, B Jacob, EH Kim, M Ahn, H Sohn… - Bioorganic & medicinal …, 2013 - Elsevier
Since the bacterial resistance to antibiotics is increasing rapidly, numerous studies have
contributed to the design and synthesis of potent synthetic mimics of antimicrobial peptides …

End group modification: Efficient tool for improving activity of antimicrobial peptide analogues towards Gram-positive bacteria

RO Jahnsen, A Sandberg-Schaal… - European Journal of …, 2015 - Elsevier
Increased incidence of infections with multidrug-resistant bacterial strains warrants an
intensive search for novel potential antimicrobial agents. Here, an antimicrobial peptide …

Synthetic antimicrobial peptidomimetics with therapeutic potential

BE Haug, W Stensen, M Kalaaji, Ø Rekdal… - Journal of medicinal …, 2008 - ACS Publications
A series of synthetic antimicrobial peptidomimetics (SAMPs) have been prepared and found
to be highly active against several Gram-negative and Gram-positive bacterial strains. These …

Lipidated α/Sulfono-α-AA heterogeneous peptides as antimicrobial agents for MRSA

S Singh, M Wang, R Gao, P Teng, T Odom… - Bioorganic & medicinal …, 2020 - Elsevier
Though antibiotics have been used for decades to treat bacterial infections, there is a great
need for new treatment methods. Bacteria are becoming resistant to conventional antibiotics …

Fine‐tuning the antimicrobial activity of β‐hairpin peptides with fluorinated amino acids

S Chowdhary, T Pelzer, M Saathoff, E Quaas… - Peptide …, 2023 - Wiley Online Library
Antimicrobial peptides (AMPs) possess bactericidal activity against a variety of pathogens
depending on an overall balance of positively charged and hydrophobic residues. Selective …

Poly-lysine peptidomimetics having potent antimicrobial activity without hemolytic activity

M Ahn, B Jacob, P Gunasekaran, RN Murugan, EK Ryu… - Amino acids, 2014 - Springer
Diversity of sequence and structure in naturally occurring antimicrobial peptides (AMPs)
limits their intensive structure–activity relationship (SAR) study. In contrast, peptidomimetics …

Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity

M Drexelius, A Reinhardt, J Grabeck… - Biochemical …, 2021 - portlandpress.com
Multidrug resistant (MDR) bacteria have adapted to most clinical antibiotics and are a
growing threat to human health. One promising type of candidates for the everlasting …