A histidine-functionalized ROS scavenging hybrid nanozyme for therapeutic application in Parkinson's disease pathogenesis

S Prasad, PS Nayak, P D'Silva - Materials Advances, 2024 - pubs.rsc.org
Oxidative stress-mediated neurotoxicity is one of the significant molecular consequences in
the progression of neurodegenerative diseases like Parkinson's disease (PD). Although …

Therapy of mitochondria-targeted hybrid nanozymes for reactive oxygen species-induced diseases

Z Wang, Z Shen, S Lin, X Mei - Applied Materials Today, 2023 - Elsevier
The development of enzyme mimetics that clear excess mitochondrial reactive oxidative
stress (ROS) could provide effective treatment for a wide variety of diseases. Herein …

A Curcumin-Decorated Nanozyme with ROS Scavenging and Anti-Inflammatory Properties for Neuroprotection

F Gao, W Liang, Q Chen, B Chen, Y Liu, Z Liu, X Xu… - Nanomaterials, 2024 - mdpi.com
Disordered reactive oxygen/nitrogen species are a common occurrence in various diseases,
which usually cause cellular oxidative damage and inflammation. Despite the wide range of …

Integrating Pt nanoparticles with carbon nanodots to achieve robust cascade superoxide dismutase-catalase nanozyme for antioxidant therapy

Y Zhang, W Gao, Y Ma, L Cheng, L Zhang, Q Liu… - Nano Today, 2023 - Elsevier
Nanozymes, nanomaterials with intrinsic enzyme mimetic activity, have emerged and been
used in a broad range of applications yet are constrained with limited catalytic efficiency …

Tri-element nanozyme PtCuSe as an ingenious cascade catalytic machine for the amelioration of Parkinson's disease-like symptoms

H Xu, X Ding, L Li, Q Li, Z Li, H Lin - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Parkinson's disease (PD), as the second most common neurodegenerative disease after
Alzheimer's, has become intractable with the increasing aging global population. The …

Nanozymes regulate redox homeostasis in ROS-related inflammation

Q Li, Y Liu, X Dai, W Jiang, H Zhao - Frontiers in Chemistry, 2021 - frontiersin.org
Reactive oxygen species (ROS), in moderate amounts, play an essential role in regulating
different physiological functions in organisms. However, increased amounts of ROS may …

Multi-shell nanocomposites based multienzyme mimetics for efficient intracellular antioxidation

Y Ai, J You, J Gao, J Wang, H Sun, M Ding, Q Liang - Nano Research, 2021 - Springer
Oxidative stress is associated with many acute and chronic inflammatory diseases.
Development of nanomaterial-based enzyme mimetics for reactive oxygen species (ROS) …

A dual synergetic nanoreactor for managing parkinson's disease by regulating inflammation and mitigating oxidative damage

Q Li, T Wu, OU Akakuru, N Song, W Liu… - Advanced Functional …, 2023 - Wiley Online Library
Glial cell‐dominated inflammatory microenvironment and neuronal damage due to oxidative
stress are major impediments to the treatment of central nervous degenerative diseases …

Multi-enzymatic activities of ultrasmall ruthenium oxide for anti-inflammation and neuroprotection

C Wu, X Han, W Feng, Z Liu, L Chen, B Zhou… - Chemical Engineering …, 2021 - Elsevier
Artificial enzymes to mimic the endogenous antioxidant system are promising candidates for
treating and manipulating the in vivo dysregulated redox homeostasis. Though progresses …

Incorporation of a biocompatible nanozyme in cellular antioxidant enzyme cascade reverses huntington's like disorder in preclinical model

A Adhikari, S Mondal, M Das, P Biswas… - Advanced …, 2021 - Wiley Online Library
The potentiality of nano‐enzymes in therapeutic use has directed contemporary research to
develop a substitute for natural enzymes, which are suffering from several disadvantages …