The Ebolavirus VP24 protein counteracts alpha/beta interferon (IFN-α/β) and IFN-γ signaling
by blocking the nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1) …

The Zaire ebolavirus protein VP24 was previously demonstrated to inhibit alpha/beta
interferon (IFN-α/β)-and IFN-γ-induced nuclear accumulation of tyrosine-phosphorylated …

Ebola virus (EBOV) infection blocks cellular production of alpha/beta interferon (IFN-α/β) and
the ability of cells to respond to IFN-α/β or IFN-γ. The EBOV VP35 protein has previously …

The Ebola virus (EBOV) protein VP24 inhibits type I and II interferon (IFN) signaling by
binding to NPI-1 subfamily karyopherin α (KPNA) nuclear import proteins, preventing their …

Zaire ebolavirus (EBOV), Bundibugyo ebolavirus (BDBV), and Reston ebolavirus (RESTV)
belong to the same genus but exhibit different virulence properties. VP24 protein, a …

Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are
characterized by early suppression of the host innate immune system. One of the proteins …

ABSTRACT The Ebola virus (EBOV) VP35 protein antagonizes the early antiviral alpha/beta
interferon (IFN-α/β) response. We previously demonstrated that VP35 inhibits the virus …

Suppression during the early phases of the immune system often correlates directly with a
fatal outcome for the host. The ebolaviruses, some of the most lethal viruses known, appear …

ABSTRACT The Ebola virus (EBOV) VP35 protein blocks the virus-induced phosphorylation
and activation of interferon regulatory factor 3 (IRF-3), a transcription factor critical for the …

Ebola virus VP35 contains a C-terminal cluster of basic amino acids required for double-
stranded RNA (dsRNA) binding and inhibition of interferon regulatory factor 3 (IRF3). VP35 …