The extracellular matrix (ECM) in skeletal muscle plays an integral role in tissue
development, structural support, and force transmission. For successful adaptation to …

Skeletal muscle is a highly dynamic and adaptive tissue, constantly changing in response to
biomechanical and metabolic demand. Such adaptation, spanning hypertrophy, atrophy …

Muscle injuries are very frequent and are associated with an inflammatory reaction that
varies in intensity. Classically the inflammatory process was considered harmful for muscle …

Bone marrow-derived mesenchymal stromal cells (BM-MSCs) represent the leading
candidate cell in tissue engineering and regenerative medicine. These cells can be easily …

Obesity is associated with skeletal muscle loss and impaired myogenesis. Increased
infiltration of proinflammatory macrophages in skeletal muscle is noted in obesity and is …

Muscle regeneration requires the coordination of muscle stem cells, mesenchymal fibro-
adipogenic progenitors (FAPs), and macrophages. How macrophages regulate the …

We examined the function of IL-10 in regulating changes in macrophage phenotype during
muscle growth and regeneration following injury. Our findings showed that the Th1 cytokine …

Tissue-resident macrophages can originate from embryonic or adult hematopoiesis. They
play important roles in a wide range of biological processes including tissue remodeling …

OBJECTIVE: Pro-inflammatory cytokines play an important role in inducing cartilage
degradation during osteoarthritis pathogenesis. Muscle is a tissue that lies near cartilage in …

Injured skeletal muscle has the capacity to regenerate through a highly coordinated
sequence of events that involves both myoblast migration and differentiation into myofibers …