Di-(2-ethylhexyl) phthalate inhibits testosterone level through disturbed hypothalamic–pituitary–testis axis and ERK-mediated 5α-Reductase 2
M Ha, X Guan, L Wei, P Li, M Yang, C Liu - Science of the Total …, 2016 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) has reproductive toxicity and can affect male
reproductive development. In order to clarify adverse effects of DEHP on testicular …
reproductive development. In order to clarify adverse effects of DEHP on testicular …
Di-2-ethylhexyl phthalate (DEHP) exposure induces sperm quality and functional defects in mice
L XueXia, L YaNan, T Zi, Z YuSheng, W ZeLin, Z Peng… - Chemosphere, 2023 - Elsevier
Abstract Di-2-ethylhexyl phthalate (DEHP) harms mammalian testis development, yet the
specific mechanism of its effect on sperm quality and function is unclear. In this study, male …
specific mechanism of its effect on sperm quality and function is unclear. In this study, male …
The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat
G Fu, J Dai, Z Li, F Chen, L Liu, L Yi, Z Teng… - Toxicology and Applied …, 2020 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a known environmental endocrine disruptor
that impairs development of testis and spermatogenesis. This study aims to explore the …
that impairs development of testis and spermatogenesis. This study aims to explore the …
Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-ovarian axis in adult female rats
T Liu, N Li, J Zhu, G Yu, K Guo, L Zhou, D Zheng… - Reproductive …, 2014 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely
present in the environment and some products with phthalate plasticizer. It has become a …
present in the environment and some products with phthalate plasticizer. It has become a …
Lactational exposure of phthalate causes long-term disruption in testicular architecture by altering tight junctional and apoptotic protein expression in Sertoli cells of …
S Sekaran, P Balaganapathy… - Human & …, 2015 - journals.sagepub.com
Di (2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental contaminant and a well-
known endocrine disruptor (ED) that interferes with the reproductive function in both humans …
known endocrine disruptor (ED) that interferes with the reproductive function in both humans …
Male rat exposure to low dose of di (2-ethylhexyl) phthalate during pre-pubertal, pubertal and post-pubertal periods: Impact on sperm count, gonad histology and …
M Oudir, H Chader, B Bouzid, K Bendisari… - Reproductive …, 2018 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is the most ubiquitous endocrine disruptor in the
environment. The present study aimed to investigate the low dose effects of DEHP on the …
environment. The present study aimed to investigate the low dose effects of DEHP on the …
Time- and Dose-Related Effects of Di-(2-ethylhexyl) Phthalate and Its Main Metabolites on the Function of the Rat Fetal Testis in Vitro
F Chauvigné, A Menuet, L Lesné, MC Chagnon… - 2009 - ehp.niehs.nih.gov
Background Endocrine-disrupting effects of phthalates are understood primarily from in
utero exposures within the fetal rat testis. Nevertheless, their path of action, dose–response …
utero exposures within the fetal rat testis. Nevertheless, their path of action, dose–response …
[HTML][HTML] Stereological analysis and transcriptome profiling of testicular injury induced by di-(2-ethylhexyl) phthalate in prepubertal rats
L Han, J Wang, T Zhao, Y Wu, Y Wei, J Chen… - Ecotoxicology and …, 2021 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) is the most common phthalate that can affect the
male reproductive system. DEHP exposure at the prepubertal stage could lead to the injury …
male reproductive system. DEHP exposure at the prepubertal stage could lead to the injury …
[HTML][HTML] Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats
Y Hong, Y Zhou, L Shen, Y Wei, C Long, Y Fu… - Ecotoxicology and …, 2021 - Elsevier
As the most abundantly used phthalate derivative, di-(2-ethylhexyl) phthalate (DEHP) leads
to reproductive disorders, especially in males. Testicular injury can be triggered when the …
to reproductive disorders, especially in males. Testicular injury can be triggered when the …
Adult exposure to di-n-butyl phthalate (DBP) induces persistent effects on testicular cell markers and testosterone biosynthesis in mice
L Källsten, R Almamoun, P Pierozan… - International Journal of …, 2022 - mdpi.com
Studies indicate that phthalates are endocrine disruptors affecting reproductive health. One
of the most commonly used phthalates, di-n-butyl phthalate (DBP), has been linked with …
of the most commonly used phthalates, di-n-butyl phthalate (DBP), has been linked with …