Although autologous bone grafts are considered a gold standard for the treatment of bone
defects, they are limited by donor site morbidities and geometric requirements. We propose …

There is an urgent, clinical need for an alternative to the use of autologous grafts for the ever
increasing number of bone grafting procedures performed annually. Herein, we describe a …

Bone tissue engineering approaches have evolved towards addressing the challenges of
tissue mimetic requirements over the years. Different strategies have been combining …

In order to solve the clinical challenges related to bone grafting, several tissue engineering
(TE) strategies have been proposed to repair critical-sized defects. Generally, the classical …

Bone tissue engineering (BTE) is a rapidly developing strategy for repairing critical-sized
bone defects to address the unmet need for bone augmentation and skeletal repair. Effective …

While bone is inherently capable of regeneration, complications such as excessive bone
loss impede healing, necessitating the use of bone grafts. In the United States alone, an …

Bone repair and regeneration is a dynamic process that involves a complex interplay
between the (1) ground substance,(2) cells, and (3) milieu. While each constituent is integral …

Biomaterials developed to treat bone defects have classically focused on bone healing via
direct, intramembranous ossification. In contrast, most bones in our body develop from a …

Treatment of large defects requires the harvest of fresh living bone from the iliac crest.
Harvest of this limited supply of bone is accompanied by extreme pain and morbidity. This …

Bone is one of the few tissues to display a true potential for regeneration. Fracture healing is
an obvious example where regeneration occurs through tightly regulated sequences of …