There is an urgent, clinical need for an alternative to the use of autologous grafts for the ever
increasing number of bone grafting procedures performed annually. Herein, we describe a …

Despite its natural healing potential, bone is unable to regenerate sufficient tissue within
critical‐sized defects, resulting in a non‐union of bone ends. As a consequence …

Although autologous bone grafts are considered a gold standard for the treatment of bone
defects, they are limited by donor site morbidities and geometric requirements. We propose …

In the past few years, great progress has been made to validate tissue engineering
strategies in preclinical studies and clinical trials on the regeneration of osteochondral …

In osteochondral tissue engineering, cell recruitment, proliferation, differentiation, and
patterning are critical for forming biologically and structurally viable constructs for repair of …

Biomaterials developed to treat bone defects have classically focused on bone healing via
direct, intramembranous ossification. In contrast, most bones in our body develop from a …

In order to solve the clinical challenges related to bone grafting, several tissue engineering
(TE) strategies have been proposed to repair critical-sized defects. Generally, the classical …

The lack of success associated with the use of bone grafts has motivated the development of
tissue engineering approaches for bone defect repair. However, the traditional tissue …

Developmental bone formation occurs via two distinct pathways. One of these,
endochondral ossification, involves the formation of a cartilage intermediate that is ultimately …

Autologous bone grafting (ABG) remains entrenched as the gold standard of treatment in
bone regenerative surgery. Consequently, many marginally successful bone tissue …