Cartilage defects are a known risk factor for osteoarthritis. Estimation of structural changes in
these defects could help us to identify high risk defects and thus to identify patients that are …

The objective of this study was to develop an in vitro cartilage degradation model that
emulates the damage seen in early-stage osteoarthritis. To this end, cartilage explants were …

Organization of the collagen network is known to be different in healthy, osteoarthritic and
repaired cartilage. The aim of the study was to investigate how the structure and properties …

Cartilage matrix mechanical function is largely determined by interactions between the
collagen fibrillar network and the proteoglycan gel. Although the molecular physics of these …

The function of articular cartilage depends on its structure and composition, sensitively
impaired in disease (eg osteoarthritis, OA). Responses of chondrocytes to tissue loading are …

The pathogenesis and pathophysiological underpinnings of cartilage degradation are not
well understood. Either mechanically or enzymatically mediated degeneration at the fibril …

OBJECTIVE: Tissue engineering is a promising method to treat damaged cartilage. So far it
has not been possible to create tissue-engineered cartilage with an appropriate structural …

Collagen damage is one of the earliest signs of cartilage degeneration and the onset of
osteoarthritis (OA), but the connection between the microscale damage and macroscale …

The remarkable compressive strength of articular cartilage arises from the mechanical
interactions between the tension-resisting collagen fibrils and swelling proteoglycan …

We present a novel algorithm combined with computational modeling to simulate the
development of knee osteoarthritis. The degeneration algorithm was based on excessive …