Current approaches to bone tissue engineering: the interface between biology and engineering

JJ Li, M Ebied, J Xu, H Zreiqat - Advanced healthcare materials, 2018 - Wiley Online Library
The successful regeneration of bone tissue to replace areas of bone loss in large defects or
at load‐bearing sites remains a significant clinical challenge. Over the past few decades …

Tissue engineering strategies for bone regeneration

AS Mistry, AG Mikos - Regenerative medicine Ii: clinical and preclinical …, 2005 - Springer
Bone loss due to trauma or disease is an increasingly serious health problem. Current
clinical treatments for critical-sized defects are problematic and often yield poor healing due …

Bone tissue engineering: recent advances and challenges

AR Amini, CT Laurencin… - Critical Reviews™ in …, 2012 - dl.begellhouse.com
The worldwide incidence of bone disorders and conditions has trended steeply upward and
is expected to double by 2020, especially in populations where aging is coupled with …

Bone tissue engineering and regeneration: from discovery to the clinic—an overview

RJ O'Keefe, J Mao - Tissue engineering part B: reviews, 2011 - liebertpub.com
A National Institutes of Health sponsored workshop “Bone Tissue Engineering and
Regeneration: From Discovery to the Clinic” gathered thought leaders from medicine …

Recent trends in the development of bone regenerative biomaterials

G Tang, Z Liu, Y Liu, J Yu, X Wang, Z Tan… - Frontiers in Cell and …, 2021 - frontiersin.org
The goal of a biomaterial is to support the bone tissue regeneration process at the defect site
and eventually degrade in situ and get replaced with the newly generated bone tissue …

A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge

T Winkler, FA Sass, GN Duda… - Bone & joint …, 2018 - boneandjoint.org.uk
Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be
challenged by a multitude of pathological conditions. While innovative approaches have …

Current state of fabrication technologies and materials for bone tissue engineering

A Wubneh, EK Tsekoura, C Ayranci, H Uludağ - Acta Biomaterialia, 2018 - Elsevier
A range of traditional and free-form fabrication technologies have been investigated and, in
numerous occasions, commercialized for use in the field of regenerative tissue engineering …

The potential impact of bone tissue engineering in the clinic

R Mishra, T Bishop, IL Valerio, JP Fisher… - Regenerative …, 2016 - Taylor & Francis
Bone tissue engineering (BTE) intends to restore structural support for movement and
mineral homeostasis, and assist in hematopoiesis and the protective functions of bone in …

Bone-tissue engineering: complex tunable structural and biological responses to injury, drug delivery, and cell-based therapies

KM Alghazali, ZA Nima, RN Hamzah… - Drug metabolism …, 2015 - Taylor & Francis
Bone loss and failure of proper bone healing continues to be a significant medical condition
in need of solutions that can be implemented successfully both in human and veterinary …

Functional biomaterials for bone regeneration: a lesson in complex biology

AR Armiento, LP Hatt… - Advanced Functional …, 2020 - Wiley Online Library
Bone is a hard yet dynamic tissue with remarkable healing capacities. Research to date has
greatly advanced the understanding of how bone heals and has led to marked success in …