Thermally-prepared polymorphic forms of cilostazol

GW Stowell, RJ Behme, SM Denton, I Pfeiffer… - Journal of …, 2002 - Elsevier
Prior to this study, cilostazol, an antithrombotic drug, was thought to exist as a single
crystalline phase with a melting point of∼ 159° C (Form A). On cooling, melts often form a …

Enhancement of solubility and dissolution of cilostazol by solid dispersion technique

JH Park, HK Choi - Archives of pharmacal research, 2015 - Springer
Cilostazol is practically insoluble in water and thus results in poor bioavailability. Only a few
approaches have been reported for improving the bioavailability of cilostazol. Solid …

Physico-chemical properties and stability of cilostazol.

T Shimizu, T Osumi, K Niimi, K Nakagawa - Arzneimittel-forschung, 1985 - europepmc.org
The physico-chemical properties of cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,
4-dihydro-2 (1H)-qui nolinone, OPC-13013), a new potential antithrombotic and vasodilating …

Physical characteristics of cilostazol–hydroxybenzoic acid cocrystals prepared using a spray drying method

M Urano, M Kitahara, K Kishi, E Goto, T Tagami… - Crystals, 2020 - mdpi.com
The cocrystal formation of pharmaceuticals can improve the various physical properties of
drugs, such as solubility, without the need for chemical modification of the drug substances …

Impact of the dissolution profile of the cilostazol cocrystal with supersaturation on the oral bioavailability

M Yoshimura, M Miyake, T Kawato… - Crystal Growth & …, 2017 - ACS Publications
The objectives of this study are to enhance the oral bioavailability of cilostazol (CLZ), which
is a poorly soluble compound, by cocrystallization and to evaluate the correlation between …

In vitro–in vivo correlation for wet-milled tablet of poorly water-soluble cilostazol

J Jinno, N Kamada, M Miyake, K Yamada… - Journal of Controlled …, 2008 - Elsevier
The purpose of the present study was to investigate oral bioavailability of an immediate
release tablet containing wet-milled crystals of a poorly water-soluble drug, cilostazol, and to …

[图书][B] Enhancing the pharmaceutical behavior of poorly soluble drugs through the formation of cocrystals and mesophases

BR Spong - 2005 - search.proquest.com
This dissertation focuses on understanding the role of molecular recognition, kinetic, and
thermodynamic events in forming solid-state supramolecular assemblies. Poorly water …

Physical and dissolution characterization of cilostazol solid dispersions prepared by hot melt granulation (HMG) and thermal adhesion granulation (TAG) methods

YC Chen, HO Ho, JD Chiou, MT Sheu - International journal of …, 2014 - Elsevier
A growing number of poorly water-soluble drug have been discovered, but the poor
bioavailability is a critical problem. In this study, physical properties and dissolution profiles …

Comparative study of different crystallization methods in the case of cilostazol crystal habit optimization

T Tari, P Szabó-Révész, Z Aigner - Crystals, 2019 - mdpi.com
The therapeutic usage of cilostazol is limited owing to its poor aqueous solubility and oral
bioavailability. Our aim was to produce cilostazol crystals with small average particle size; …

Preparation and evaluation of oral controlled-release cilostazol formulation: pharmacokinetics and antithrombotic efficacy in dogs and healthy male Korean …

KH Shin, G Yoon, IS Yoon… - Journal of Pharmacy and …, 2014 - academic.oup.com
Objectives To prepare oral controlled-release cilostazol formulations and evaluate their
pharmacokinetics and pharmacodynamics in dogs and humans compared with a …