Enhancement of wettability and dissolution properties of cilostazol using the supercritical antisolvent process: effect of various additives

MS Kim, JS Kim, SJ Hwang - Chemical and Pharmaceutical Bulletin, 2010 - jstage.jst.go.jp
The aim of this study was to improve wettability and dissolution rate of a poorly water-soluble
drug, cilostazol, using the supercritical antisolvent (SAS) process. The solid state of particles …

[HTML][HTML] Hydrolytic degradation profile and RP-HPLC estimation of cilostazol in tablet dosage form

PK Basniwal, PK Shrivastava, D Jain - Indian journal of …, 2008 - ncbi.nlm.nih.gov
A simple, selective, precise and stability-indicating high-performance liquid-
chromatographic method of analysis of cilostazol in pharmaceutical dosage form was …

[HTML][HTML] Formulation of cilostazol spherical agglomerates by crystallo-co-agglomeration technique and optimization using design of experimentation

SS Deshkar, GR Borde, RN Kale… - International Journal …, 2017 - ncbi.nlm.nih.gov
Materials and Methods: Cilostazol agglomerates were prepared using various polymers with
varying concentration of hydroxypropyl methylcellulose E 50 (HPMC E50), polyvinyl …

Cocrystal Synthesis through Crystal Structure Prediction

YA Abramov, L Iuzzolino, Y Jin, G York… - Molecular …, 2023 - ACS Publications
Crystal structure prediction (CSP) is an invaluable tool in the pharmaceutical industry
because it allows to predict all the possible crystalline solid forms of small-molecule active …

Crystal form I of clarithromycin

JH Liu, DA Riley, SG Spanton - US Patent 5,858,986, 1999 - Google Patents
We have discovered that 6-O-methylerythromycin A can exist in at least tWo distinct
crystalline forms, Which for the sake of identi? cation are designated “Form I” and “Form II” …

Crystal structures of tetramorphic forms of donepezil and energy/temperature phase diagram via direct heat capacity measurements

Y Park, J Lee, SH Lee, HG Choi, C Mao… - Crystal growth & …, 2013 - ACS Publications
Donepezil is used for the palliative treatment of mild to moderate dementia of the
Alzheimer's disease. Donepezil crystallized as four solvent-free polymorphs including forms …

Solid-state stability assessment of controlled release tablets containing Carbopol® 971P

VR Goskonda, IK Reddy, MJ Durrani, W Wilber… - Journal of controlled …, 1998 - Elsevier
A tablet formulation containing dyphylline, Carbomer, magnesium stearate, talc and lactose
was prepared by the direct compression method. The objective of the study was to assess …

Investigation of solid-state stability of selected bioactive compounds

W Xu - 1997 - search.proquest.com
Chemical stability is a critical issue in the drug development process. Since a vast majority of
drug products are administered as solid dosage forms, understanding the molecular details …

Rational polymorph screening based on slow cooling crystallization of poorly soluble mebendazole

M Karashima, K Kimoto, T Kojima, Y Ikeda - Journal of crystal growth, 2014 - Elsevier
During polymorph screening, the possibility of overlooking the most stable form of a poorly
soluble drug is relatively high due to its slow nucleation rate. To develop a rational …

[PDF][PDF] HPTLC determination of cilostazol in pharmaceutical dosage forms

J Kurien, P Jayasekhar, J John - Int J Adv Res, 2014 - researchgate.net
Cilostazol is chemically 6-[4-1 (-cyclohexyl-1H-tetrazol-5-yl-butoxyl] 3-4-dihydro-2 (1H)-
quinolinone1. Cilostazol and its metabolites are cyclic adenosine monophosphate (cAMP) …