We have discovered that 6-O-methylerythromycin A can exist in at least tWo distinct
crystalline forms, Which for the sake of identi? cation are designated “Form I” and “Form II” …

Chemical stability is a critical issue in the drug development process. Since a vast majority of
drug products are administered as solid dosage forms, understanding the molecular details …

Cilostazol is chemically 6-[4-1 (-cyclohexyl-1H-tetrazol-5-yl-butoxyl] 3-4-dihydro-2 (1H)-
quinolinone1. Cilostazol and its metabolites are cyclic adenosine monophosphate (cAMP) …

Donepezil is used for the palliative treatment of mild to moderate dementia of the
Alzheimer's disease. Donepezil crystallized as four solvent-free polymorphs including forms …

During polymorph screening, the possibility of overlooking the most stable form of a poorly
soluble drug is relatively high due to its slow nucleation rate. To develop a rational …

In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous
solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic …

A tablet formulation containing dyphylline, Carbomer, magnesium stearate, talc and lactose
was prepared by the direct compression method. The objective of the study was to assess …

Purpose The fixed-dose combination drug products have been increasingly used to treat
some complex diseases. A cocrystal containing two therapeutic components, named as a …

The polymorphism of sulindac was investigated by Raman investigations, mainly in the low-
wavenumber region in order to analyze the influence of the amorphization method on …

The crystallization of ciprofloxacin—an antibacterial fluoroquinolone compound—with
salicylic acid resulted in the isolation of five distinct solid forms of the drug, namely, an …