Many new molecular entities targeted for pharmaceutical applications face serious
development challenges because of poor water solubility. Although particle engineering …

The possibility of decreasing the solubility of the antidepressant drug venlafaxine
hydrochloride by formation of molecular salts with organic acids accepted by the …

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor. The
native crystal structure of nimesulide (or Form I) has been characterized in the literature by X …

Solid-state properties of active pharmaceutical compounds are closely related to their
dissolution behavior and bioavailability, and understanding their phase behavior leads to …

Roxifiban was found to exist in two polymorphic forms. The polymorphs were detected by X‐
ray powder diffraction and solid‐state carbon nuclear magnetic resonance. A slight …

Delavirdine mesylate was recrystallized from solution under a variety of conditions. Seven
crystal forms and a stable amorphous phase were isolated from solution. Two of these …

Poorly water-soluble drug substances that exhibit high melting points are often difficult to
successfully process by fusion-based techniques. The purpose of this study was to identify a …

A full solid-state characterization of risperidone was conducted using differential scanning
calorimetry (DSC), thermogravimetry (TG), powder X-ray diffraction (PXRD), Fourier …

This study presents characterization and physicochemical properties of a new cocrystal of
ketoconazole (KTZ). Cocrystal formation of KTZ with two different coformers, ie nicotinamide …

The antiarrhythmic agent moricizine hydrochloride exhibits a single melting-decomposition
endotherm peak at temperatures ranging from 209 to 214.5° C (Form I) when recrystallized …