The predominant product of cyclooxygenase (COX) activity in the colon, prostaglandin (PG)
E 2 promotes intestinal tumorigenesis. Expression of the PGE 2 receptor EP4 is upregulated …

Accumulating evidence indicates that elevated levels of prostaglandin E2 (PGE2) can
increase intestinal epithelial cell proliferation, and thus play a role in colorectal …

Approximately two decades have passed since E-type prostanoid 4 (EP4) receptors were
cloned, and the signaling pathways mediated by these receptors have since been …

Abstract Background Prostaglandin E 2 (PGE 2) is the major product of Cyclooxygenase-2
(COX-2) in colorectal cancer (CRC). We aimed to assess PGE 2 cell surface receptors (EP 1 …

Abstract Cyclooxygenase-2 and prostaglandin E2 (PGE2) levels are increased in colorectal
cancers and a subset of adenomas. PGE2 signaling through the EP4 receptor has …

The importance of the prostaglandin (PG) synthesis pathway, particularly the rate-limiting
enzymatic step catalyzed by cyclooxygenase, to colorectal carcinogenesis and development …

Accumulating evidence indicates that overproduction of prostanoids attributable to
overexpression of cyclooxygenase-2 (COX-2) plays an important role in colon …

Increased expressions of cyclooxygenase-2 (COX-2) and its downstream metabolite,
prostaglandin E 2 (PGE 2), are well documented events in the development of colorectal …

Background and aims: Involvement of prostaglandin E2 (PGE2) receptors EP1, EP2, and
EP4 in the formation of aberrant crypt foci (ACF) and/or intestinal polyps has been …

The number of colorectal cancer (CRC) patients is increasing worldwide. Accumulating
evidence has shown that the tumor microenvironment (TME), including macrophages …