Readily Available Oral Prebiotic Protein Reactive Oxygen Species Nanoscavengers for Synergistic Therapy of Inflammation and Fibrosis in Inflammatory Bowel …

Y Yu, D Yang, B Lin, L Zhu, C Li, X Li - ACS nano, 2024 - ACS Publications
A significant gap exists in the demand for safe and effective drugs for inflammatory bowel
disease (IBD), and its associated intestinal fibrosis. As oxidative stress plays a central role in …

Bi-functional astaxanthin macromolecular nanocarriers to alleviate dextran sodium sulfate-induced inflammatory bowel disease

X Zhang, W Su, Y Chen, S Xing, AM Abd El-Aty… - International Journal of …, 2024 - Elsevier
Dextran sulfate sodium is one of the important members in the field of polysaccharide
biotechnology, which can induce inflammatory bowel disease (IBD) in the gastrointestinal …

Payload‐free protein nanoparticles target inflamed colons to restore intestinal barrier integrity for effectively treating inflammatory bowel diseases

M Yang, H Shen, S Zhong, Z Xu, X Liu, W Wu… - …, 2024 - Wiley Online Library
Anti‐inflammatory compounds, delivered as a payload to the gastrointestinal tract (GIT) by
carriers, still cannot treat inflammatory bowel diseases without avoiding side effects. Here …

Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease

Q Hu, J Li, T Wang, X Xu, Y Duan, Y Jin - ACS nano, 2024 - ACS Publications
Inflammatory bowel diseases (IBDs) refer to multifaceted disorders in the intestinal
microenvironment and microbiota homeostasis. In view of the broad bioactivity and high …

Microenvironment responsive pod-structured astaxanthin nanocarrier for ameliorating inflammatory bowel disease

J Wang, Y Chen, L Han, S Xia, X Zhang, P Xue… - Chinese Chemical …, 2024 - Elsevier
Anti-inflammatory drugs targeting inflammatory bowel disease (IBD) have attracted
considerable attention but still face low therapeutic outcomes and frequent side effects …

An orally-administered nanotherapeutics with carbon monoxide supplying for inflammatory bowel disease therapy by scavenging oxidative stress and restoring gut …

X Zhang, Z Yuan, J Wu, Y He, G Lu, D Zhang, Y Zhao… - ACS …, 2023 - ACS Publications
Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant
limitations due to their potential off-target systemic side-effects. Currently, there is a lack of …

[HTML][HTML] Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy

S Lin, H Zhao, C Xu, P Zhang, X Mei, D Jiang - Materials & Design, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by
complex interactions between genetic, environmental, and immune factors. Sulfasalazine …

A proresolving peptide nanotherapy for site‐specific treatment of inflammatory bowel disease by regulating proinflammatory microenvironment and gut microbiota

C Li, Y Zhao, J Cheng, J Guo, Q Zhang… - Advanced …, 2019 - Wiley Online Library
The incidence and prevalence of inflammatory bowel disease (IBD) increases steadily
worldwide. There is an urgent need for effective and safe IBD therapies. Accelerated …

Mucoadhesive probiotic backpacks with ROS nanoscavengers enhance the bacteriotherapy for inflammatory bowel diseases

J Liu, Y Wang, WJ Heelan, Y Chen, Z Li, Q Hu - Science advances, 2022 - science.org
Inflammatory bowel diseases (IBDs) are often associated with elevated levels of reactive
oxygen species (ROS) and highly dysregulated gut microbiota. In this study, we synthesized …

Attenuation of inflammatory bowel disease by oral administration of mucoadhesive polydopamine-coated yeast β-glucan via ROS scavenging and gut microbiota …

F Yang, Y Su, C Yan, T Chen, PCK Cheung - Journal of …, 2024 - Springer
Abstract Treatment for inflammatory bowel disease (IBD) is challenging since current anti-
inflammatory and immunosuppressive therapies do not address the underlying causes of …