Recent evidence attributed important influence of chemokines and their receptors on
motility, homing, and proliferation of cancer cells at specific metastatic sites. Here we report …

The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …

Background The stromal cell-derived factor-1/CXC chemokine receptor-4 (SDF-1/CXCR4)
signal has been shown to be important in various immunological reactions. Recent studies …

There is growing evidence that several chemokine receptors including CXCR3 contribute to
metastasis of breast and other cancers, however, in order to target CXCR3 effectively, it is …

Breast cancer is one of the leading causes of cancer related deaths worldwide. Breast
cancer-related mortality is associated with the development of metastatic potential of primary …

Breast tumor cells express the chemokine receptor CXCR3, which binds the ligands CXCL9,
CXCL10, and CXCL11. CXCR3 and other chemokine receptors may mediate tumor …

CXCR4 and its ligand CXCL12 can promote the proliferation, survival, and invasion of
cancer cells. They have been shown to play an important role in regulating metastasis of …

Expression of the chemokine receptor CXCR4 has been linked with increased metastasis
and decreased clinical prognosis in breast cancer. The current paradigm dictates that …

The acquisition of a metastatic phenotype in breast epithelial cells is a progressive process,
influenced by a large variety of cellular and soluble factors. Of these, members of the …

The abilities of chemokines in orchestrating cellular migration are utilised by different (patho-
) biological networks including malignancies. However, except for CXCR4/CXCL12, little is …