Prostaglandin E2 Promotes Lung Cancer Cell Migration via EP4-βArrestin1-c-Src Signalsome
JI Kim, V Lakshmikanthan, N Frilot, Y Daaka - Molecular Cancer Research, 2010 - AACR
Many human cancers express elevated levels of cyclooxygenase-2 (COX-2), an enzyme
responsible for the biosynthesis of prostaglandins. Available clinical data establish the …
responsible for the biosynthesis of prostaglandins. Available clinical data establish the …
Prostaglandin E2 Activates Mitogen-Activated Protein Kinase/Erk Pathway Signaling and Cell Proliferation in Non–Small Cell Lung Cancer Cells in an Epidermal …
K Krysan, KL Reckamp, H Dalwadi, S Sharma… - Cancer research, 2005 - AACR
Abstract Cyclooxygenase 2 (COX-2) overexpression is found in a wide variety of human
cancers and is linked to all stages of tumorigenesis. Elevated tumor COX-2 expression is …
cancers and is linked to all stages of tumorigenesis. Elevated tumor COX-2 expression is …
Roles of a prostaglandin E‐type receptor, EP3, in upregulation of matrix metalloproteinase‐9 and vascular endothelial growth factor during enhancement of tumor …
H Amano, Y Ito, T Suzuki, S Kato, Y Matsui… - Cancer …, 2009 - Wiley Online Library
Cyclooxygenase (COX)‐2 is known to correlate with poor cancer prognosis and to contribute
to tumor metastasis. However, the precise mechanism of this phenomenon remains …
to tumor metastasis. However, the precise mechanism of this phenomenon remains …
[HTML][HTML] PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells
Abstract Prostaglandin E 2 (PGE 2) interacts with tyrosine kinases receptor signaling in both
tumor and stromal cells supporting tumor progression. Here we demonstrate that in non …
tumor and stromal cells supporting tumor progression. Here we demonstrate that in non …
Prostaglandin E2 activates Src signaling in lung adenocarcinoma cell via EP3
T Yamaki, K Endoh, M Miyahara, I Nagamine… - Cancer letters, 2004 - Elsevier
Accumulating evidence suggests that overproduction of prostaglandin (PG) E2 attributable
to induction of cyclooxygenase-2 plays an important role in the development of lung …
to induction of cyclooxygenase-2 plays an important role in the development of lung …
Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism
L Yang, Y Huang, R Porta, K Yanagisawa, A Gonzalez… - Cancer research, 2006 - AACR
Abstract Prostaglandin E2 (PGE2), one of the major metabolites of cyclooxygenase-2, has
been implicated in tumorigenesis and tumor progression in several human cancers …
been implicated in tumorigenesis and tumor progression in several human cancers …
Prostaglandin E receptor EP1 suppresses breast cancer metastasis and is linked to survival differences and cancer disparities
X Ma, N Kundu, OB Ioffe, O Goloubeva, R Konger… - Molecular Cancer …, 2010 - AACR
Cyclooxygenase-2 is frequently overexpressed and associated with poor prognosis in
breast cancer. The cyclooxygenase-2 product prostaglandin E2 elicits cellular responses …
breast cancer. The cyclooxygenase-2 product prostaglandin E2 elicits cellular responses …
Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation
J Jiang, R Dingledine - Journal of Pharmacology and Experimental …, 2013 - ASPET
Population studies, preclinical, and clinical trials suggest a role for cyclooxygenase-2 (COX-
2, PTGS2) in tumor formation and progression. The downstream prostanoid receptor …
2, PTGS2) in tumor formation and progression. The downstream prostanoid receptor …
Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent …
M Dohadwala, RK Batra, J Luo, Y Lin, K Krysan… - Journal of Biological …, 2002 - ASBMB
Tumor cyclooxygenase-2 (COX-2) expression is known to be associated with enhanced
tumor invasiveness. In the present study, we evaluated the importance of the COX-2 product …
tumor invasiveness. In the present study, we evaluated the importance of the COX-2 product …
Cooperation between prostaglandin E2 and epidermal growth factor receptor in cancer progression: A dual target for cancer therapy
F Finetti, L Paradisi, C Bernardi, M Pannini, L Trabalzini - Cancers, 2023 - mdpi.com
Simple Summary Inflammation is the biological response of the body to damaging and toxic
stimuli, and is a positive event that evolves with the resolution of critical events (acute …
stimuli, and is a positive event that evolves with the resolution of critical events (acute …