Cyclooxygenase-2 (COX-2) is constitutively expressed in most human primary carcinomas
and with its synthesized product, prostaglandin E2 (PGE2), appears to play important roles …

Cyclooxygenase-2 (COX-2) overexpression is seen in many malignancies including lung
cancer. Elevated tumor prostaglandin E2 (PGE2), a major COX-2 metabolite, levels have …

Abstract Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin H synthase, has
been implicated in the progression of human lung adenocarcinoma. However, the …

Cyclooxygenase (COX) and its prostanoid metabolites have been implicated in the control of
cell survival; however, their role as mitogens remains undefined. To better understand the …

It is well established that high cyclooxygenase-2 (COX-2) expression contributes to the
aggressive behavior of breast and other malignancies. Due to concerns regarding the safety …

The mechanisms underlying the effects of COX‐2 on tumor lymphangiogenesis remain
largely undefined. Here, the human lung cancer cell lines A549, 95D, Anip973, and AGZY83 …

Abstract Cyclooxygenase-2 (COX-2) expression in epithelial tumors is frequently associated
with a poor prognosis. In a murine model of metastatic breast cancer, we showed that COX-2 …

We reported that cyclo-oxygenase (COX)-2 expression in human breast cancer stimulated
cancer cell migration and invasiveness, production of vascular endothelial growth factor …

Background: Manipulating prostaglandin (PG) production modulates tumor development.
Elevated PGI 2 production prevents murine lung cancer, while decreasing PGE 2 content …

Over the past decade cyclooxygenase-2-derived prostaglandins have been implicated in the
development and progression of many types of cancer. Recently our laboratory has shown …