[HTML][HTML] Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells
YM Zhu, NSM Azahri, DCW Yu, PJ Woll - BMC cancer, 2008 - Springer
Abstract Background Cyclooxygenase (COX)-2 has been implicated in tumour progression,
angiogenesis and metastasis in non-small cell lung cancer (NSCLC). We speculated that …
angiogenesis and metastasis in non-small cell lung cancer (NSCLC). We speculated that …
[HTML][HTML] Prostaglandin E2-induced COX-2 expressions via EP2 and EP4 signaling pathways in human LoVo colon cancer cells
HH Hsu, YM Lin, CY Shen, MA Shibu, SY Li… - International journal of …, 2017 - mdpi.com
Metastasis is the most dangerous risk faced by patients with hereditary non-polyposis colon
cancer (HNPCC). The expression of matrix metalloproteinases (MMPs) has been observed …
cancer (HNPCC). The expression of matrix metalloproteinases (MMPs) has been observed …
[HTML][HTML] EP4 as a therapeutic target for aggressive human breast cancer
M Majumder, P Nandi, A Omar, KC Ugwuagbo… - International journal of …, 2018 - mdpi.com
G-protein-coupled receptors (GPCRs, also called seven-transmembrane or heptahelical
receptors) are a superfamily of cell surface receptor proteins that bind to many extracellular …
receptors) are a superfamily of cell surface receptor proteins that bind to many extracellular …
Selective Cox-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signaling
Z Wang, Z Fan, H Jiang, J Qu - Carcinogenesis, 2013 - academic.oup.com
Increasing evidence has suggested that high expression level of cyclooxygenase-2 (Cox-2)
is associated with the malignancies of non–small cell lung cancer (NSCLC), leading to a …
is associated with the malignancies of non–small cell lung cancer (NSCLC), leading to a …
[HTML][HTML] Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity
B Liu, L Qu, S Yan - Cancer cell international, 2015 - Springer
Abstract Cyclooxygenase-2 (COX-2), an inducible form of the enzyme that catalyzes the first
step in the synthesis of prostanoids, is associated with inflammatory diseases and …
step in the synthesis of prostanoids, is associated with inflammatory diseases and …
Prostaglandin E2 produced by inducible COX-2 and mPGES-1 promoting cancer cell proliferation in vitro and in vivo
D Ruan, SP So - Life sciences, 2014 - Elsevier
Aim Many cancers originate and flourish in a prolonged inflammatory environment. Our aim
is to understand the mechanisms of how the pathway of prostaglandin E 2 (PGE 2) …
is to understand the mechanisms of how the pathway of prostaglandin E 2 (PGE 2) …
Cyclooxygenase-2–Dependent Regulation of E-Cadherin: Prostaglandin E2 Induces Transcriptional Repressors ZEB1 and Snail in Non–Small Cell Lung Cancer
M Dohadwala, SC Yang, J Luo, S Sharma, RK Batra… - Cancer research, 2006 - AACR
Abstract Elevated tumor cyclooxygenase-2 (COX-2) expression is associated with tumor
invasion, metastasis, and poor prognosis in non–small cell lung cancer (NSCLC). Here, we …
invasion, metastasis, and poor prognosis in non–small cell lung cancer (NSCLC). Here, we …
Tumor Cyclooxygenase-2/Prostaglandin E2–Dependent Promotion of FOXP3 Expression and CD4+CD25+ T Regulatory Cell Activities in Lung Cancer
S Sharma, SC Yang, L Zhu, K Reckamp, B Gardner… - Cancer research, 2005 - AACR
Abstract Cyclooxygenase (COX)-2 and its product prostaglandin (PG) E2 underlie an
immunosuppressive network that is important in the pathogenesis of non–small cell lung …
immunosuppressive network that is important in the pathogenesis of non–small cell lung …
Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis
G Zhang, D Panigrahy, SH Hwang… - Proceedings of the …, 2014 - National Acad Sciences
Prostaglandins derived from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic
acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH) pathway are …
acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH) pathway are …
Prostanoid receptor signaling relevant to tumor growth and angiogenesis
M Majima, H Amano, I Hayashi - Trends in pharmacological sciences, 2003 - cell.com
Non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit the cyclooxygenases (COXs)
and suppress prostaglandin (PG) synthesis have been used widely as anti-inflammatory …
and suppress prostaglandin (PG) synthesis have been used widely as anti-inflammatory …