Infection rates, severity, and fatalities due to COVID‐19, the pandemic mediated by SARS‐
CoV‐2, vary greatly between countries. With few exceptions, these are lower in East and …

Background: Epidemiologic studies have reported that the geographical distribution of the
prevalence of allelic variants of serine protein inhibitor-A1 (SERPINA1) and severe cases of …

Alpha-1 antitrypsin deficiency (AATD) is highly prevalent in Portugal. It is estimated that 1:
5249 individuals have a ZZ genotype, and 1: 281 have a SZ genotype [1]. Patients with …

Background: Host proteases have been suggested to be crucial for dissemination of MERS,
SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane …

α1-Antitrypsin deficiency and the risk of COVID-19: an urgent call to action - The Lancet
Respiratory Medicine Skip to Main Content Advertisement The Lancet Respiratory Medicine …

The transmembrane serine protease 2 (TMPRSS2) is the major host protease that enables
entry of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) into host …

Entry of SARS-CoV-2 is facilitated by endogenous and exogenous proteases. These
proteases proteolytically activate the SARS-CoV-2 spike glycoprotein and are key …

The clinical manifestations of COVID-19 are heterogeneous: 46.4% of patients admitted into
hospital reported to have at least one comorbidity. Comorbidities such as COPD, diabetes …

In December 2019, a new infectious respiratory disease emerged in Wuhan, Hubei
province, China (Huang et al., 2020; Wang et al., 2020; Zhu et al., 2020). It diffused rapidly …

Among 68 countries in the world, severity of the COVID-19 epidemic was correlated with the
prevalence of α-1 antitrypsin (AAT) deficiency. For the severe variant, PI* Z, the correlation …