The clinical manifestations of COVID-19 are heterogeneous: 46.4% of patients admitted into
hospital reported to have at least one comorbidity. Comorbidities such as COPD, diabetes …

Alpha-1 antitrypsin deficiency (AATD) is highly prevalent in Portugal. It is estimated that 1:
5249 individuals have a ZZ genotype, and 1: 281 have a SZ genotype [1]. Patients with …

At the time when WHO reports that Italy is currently the fifth country in the world for number of
cases of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection (225 …

Background: Epidemiologic studies have reported that the geographical distribution of the
prevalence of allelic variants of serine protein inhibitor-A1 (SERPINA1) and severe cases of …

α1-Antitrypsin deficiency and the risk of COVID-19: an urgent call to action - The Lancet
Respiratory Medicine Skip to Main Content Advertisement The Lancet Respiratory Medicine …

Alpha1-antitrypsin deficiency arises due to mutations in alpha1-antitrypsin (AAT) gene and
represents the most prominent genetic predisposition to chronic obstructive pulmonary …

The coronavirus disease of 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infections, continues to present an unprecedented …

Among 68 countries in the world, severity of the COVID-19 epidemic was correlated with the
prevalence of α-1 antitrypsin (AAT) deficiency. For the severe variant, PI* Z, the correlation …

Abstract Corona Virus Disease 2019 (COVID-19) has emerged as a pandemic leading to
unprecedented disruption of global health and economy. Transmembrane protease serine 2 …

Abstract Introduction Alpha 1 antitrypsin (A1AT) is the major human blood serine protease
inhibitor. Transmembrane serine protease 2 (TMPRSS2), which is crucial for SARS-CoV-2 …