The phagocyte reduced NAD phosphate (NADPH) oxidase generates superoxide, the
precursor to reactive oxygen species (ROS) that has both antimicrobial and …

The leukocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase generates
reactive oxygen species essential in microbial killing and regulation of inflammation …

Neutrophils play a prominent role in host defense. Phagocytosis of bacteria leads to the
formation of an active NADPH oxidase complex that generates reactive oxygen species for …

NADPH oxidase is a crucial enzyme in mediating antimicrobial host defense and in
regulating inflammation. Patients with chronic granulomatous disease, an inherited disorder …

Neutrophils are phagocytic innate immune cells essential for killing bacteria via activation of
a wide variety of effector responses and generation of large amounts of reactive oxygen …

The generation of reactive oxygen species (ROS) by the reduced nicotinamide adenine
dinucleotide phosphate (NADPH) oxidase complex plays a critical role in the antimicrobial …

Neutrophils are capable of producing significant amounts of reactive oxygen species (ROS)
by the phagocyte NADPH oxidase, which consists of membrane-bound and cytoplasmic …

Background Chronic granulomatous disease (CGD), an inherited disorder of the NADPH
oxidase in which phagocytes are defective in generating superoxide anion and downstream …

Mutations in the leukocyte NADPH oxidase that abrogate superoxide production result in
chronic granulomatous disease (CGD), an inherited immunodeficiency associated with …

Chronic granulomatous disease (CGD) is caused by mutations in genes that encode the
NADPH-oxidase and result in a failure of phagocytic cells to produce reactive oxygen …