Lung cancer is the leading cause of cancer mortality worldwide, and at only 18%, it has one
of the lowest 5-year survival rates of all malignancies. With its highly complex mutational …

Purpose Inflammation plays a critical role in cancer progression. In this study we investigate
the pro-tumorigenic activities and gene expression profiles of lung cancer cells after …

Macrophages are the dominant leukocyte population found in the tumor microenvironment.
Accumulating evidence suggests that these tumor-associated macrophages (TAMs) actively …

Introduction: It is reported that cancer may arise in chronically inflamed tissue. There is
mounting evidence suggesting that the connection between inflammation and lung cancer is …

How neoplastic cells respond to therapy is not solely dependent on the complexity of the
genomic aberrations they harbor but is also regulated by numerous dynamic properties of …

Lung cancer is the deadliest malignancy worldwide. An inflammatory microenvironment is a
key factor contributing to lung tumor progression. Tumor-Associated Macrophages (TAMs) …

Tumor-associated macrophages (TAMs) are a major component of the tumor immune
microenvironment (TIME) and are associated with a poor prognostic factor in several …

Tumor-associated macrophages are one of the major constituents of tumor stroma in many
solid tumors and there is compelling preclinical and clinical evidence that macrophages …

Macrophages are innate immune cells with evolutionarily conserved functions in tissue
maintenance and host defense. As such, macrophages are among the first hematopoietic …

Macrophages are present in all vertebrate tissues and have emerged as multifarious cells
with complex roles in development, tissue homeostasis, and disease. Macrophages are a …