Mitochondrial Ca2+ ([Ca2+] M) uptake through its Ca2+ uniporter (MCU) is central to many
cell functions such as bioenergetics, spatiotemporal organization of Ca2+ signals, and …

While mitochondria oxidative phosphorylation is broadly regulated, the impact of
mitochondrial Ca2+ on substrate flux under both physiological and pathological conditions …

Human mitochondria are complex and highly dynamic biological systems, comprised of over
a thousand parts and evolved to fully integrate into the specialized intracellular signaling …

Each model used in the work referred to by Rutter et al.(1) addressed certain aspects of
mitochondrial biology, and together, they fully support the conclusions made. Please note …

Mitochondria sense, shape and integrate signals, and thus function as central players in
cellular signal transduction. Ca 2+ waves and redox reactions are two such intracellular …

Ca2+ ions serve as pleiotropic second messengers in the cell, regulating several cellular
processes. Mitochondria play a fundamental role in Ca2+ homeostasis since mitochondrial …

Coenzyme Q (CoQ, ubiquinone) is the electron‐carrying lipid in the mitochondrial electron
transport system (ETS). In mammals, it serves as the electron acceptor for nine mitochondrial …

Background Mitochondria were originally found and studied simply as a cellular power-plant
in the first half of the 20th century (Drago et al., 2011). Soon it was also recognized that Ca …

Coenzyme Q (CoQ) is an isoprenylated quinone that is essential for cellular respiration and
is synthesized in mitochondria by the combined action of at least nine proteins (COQ1–9) …

Mitochondrial Ca 2+ uptake via the uniporter is central to cell metabolism, signaling, and
survival. Recent studies identified MCU as the uniporter's likely pore and MICU1, an EF …