Genetically engineered pigs are increasingly recognized as valuable models for the study of
human disease. Immunohistochemical study of cellular markers of disease is an important …

Inflammation is a common feature in several types of lung disease and is a frequent end
point to validate lung disease models, evaluate genetic or environmental impact on disease …

In this chapter, we will provide an overview of (1) the structure and function of the respiratory
system, highlighting similarities and differences between humans and laboratory animals;(2) …

The porcine model has contributed significantly to biomedical research over many decades.
The similar size and anatomy of pig and human organs make this model particularly …

By definition no model is perfect, and this also holds for biology and health sciences. In
medicine, murine models are, and will be indispensable for long, thanks to their reasonable …

Investigation and studies of pulmonary diseases and injuries require pre-clinical animal
models. The rabbit lung model is widely used and allows for a diverse set of readouts …

Norway (Rattus norvegicus) and black rats (Rattus rattus) are common peridomestic
species, yet little is known about wild rat ecology, including their natural diseases. We …

Parenchymal lung diseases comprise a wide variety of diseases, with different etiologies,
pathogeneses and prognoses. This perspective provides an overview of two different …

Subsequent to the first report in the 1940s on incubation of tissue sections with fluorescein-
conjugated antibodies for localization of antigens, a great number of modifications were …

Inflammation is a risk factor for the development of many types of neoplasia, including skin,
colon, gastric, and mammary cancers, among others. Chronic pulmonary diseases, such as …