In vitro synergistic activities of the hybrid antimicrobial peptide MelitAP-27 in combination with conventional antibiotics against planktonic and biofilm forming bacteria

A Almaaytah, A Alnaamneh, A Abualhaijaa… - International Journal of …, 2016 - Springer
The extensive use of antibiotics for the treatment of human infections during the last few
decades has led to a dramatic increase in the emergence of multidrug-resistant bacteria …

Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus …

HM Jindal, K Zandi, KC Ong, RD Velayuthan, SM Rasid… - PeerJ, 2017 - peerj.com
Background Antimicrobial peptides (AMPs) are of great potential as novel antibiotics for the
treatment of broad spectrum of pathogenic microorganisms including resistant bacteria. In …

New approaches in peptide antibiotics

M Vaara - Current opinion in pharmacology, 2009 - Elsevier
The emergence and rapid spread of extremely multiresistant bacteria necessitates every
effort to develop novel antibacterial agents. Host-derived antimicrobial peptides (AMPs) …

Characterisation and evaluation of synthetic antimicrobial peptides against Bacillus globigii, Bacillus anthracis and Burkholderia thailandensis

RM Dawson, J McAllister, CQ Liu - International journal of antimicrobial …, 2010 - Elsevier
Antimicrobial peptides (AMPs) are produced by all forms of living organisms and represent a
novel class of antibiotics to treat infectious diseases. In this study, 29 AMPs of varying length …

Identification and design of antimicrobial peptides for therapeutic applications

A Ahmad, E Ahmad, G Rabbani… - Current Protein and …, 2012 - ingentaconnect.com
Indiscriminate use of antibiotics has led to a rapid increase of antibiotic resistance among
microbes which has increased the need to develop novel antimicrobial agents to fight …

Activity of tick antimicrobial peptide from Ixodes persulcatus (persulcatusin) against cell membranes of drug-resistant Staphylococcus aureus

N Miyoshi, E Isogai, K Hiramatsu, T Sasaki - The Journal of Antibiotics, 2017 - nature.com
Persulcatusin (IP), which is an antimicrobial peptide found in Ixodes persulcatus midgut, is
active against Gram-positive bacteria such as Staphylococcus aureus. Multidrug-resistant …

K1K8: an Hp1404-derived antibacterial peptide

Z Li, G Liu, L Meng, W Yu, X Xu, W Li, Y Wu… - Applied microbiology and …, 2016 - Springer
As an alternative class of antimicrobial agents used to overcome drug-resistant infections,
antimicrobial peptides (AMPs) have recently gained significant attention. In this study, we …

Antimicrobial peptide isolated from Bacillus amyloliquefaciens K14 revitalizes its use in combinatorial drug therapy

S Regmi, YH Choi, YS Choi, MR Kim, JC Yoo - Folia microbiologica, 2017 - Springer
The present study was performed to evaluate the antibacterial activities of an antimicrobial
peptide (CSpK14) and the synergies thereof with β-lactams against vancomycin-resistant …

Antibacterial activities of amphiphilic cyclic cell-penetrating peptides against multidrug-resistant pathogens

D Oh, J Sun, A Nasrolahi Shirazi… - Molecular …, 2014 - ACS Publications
Multidrug-resistant pathogens have become a major public health concern. There is a great
need for the development of novel antibiotics with alternative mechanisms of action for the …

Bactericidal activity and synergy studies of peptide AP-CECT7121 against multi-resistant bacteria isolated from human and animal soft tissue infections

G Delpech, M Bistoletti, M Ceci, S Lissarrague… - Probiotics and …, 2017 - Springer
AP-CECT7121 is an antimicrobial peptide, produced by Enterococcus faecalis CECT7121,
with bactericidal activity against Gram-positive bacteria. The aim of this study was to …