The non-canonical NF-κB pathway is an important arm of NF-κB signaling that
predominantly targets activation of the p52/RelB NF-κB complex. This pathway depends on …

The noncanonical nuclear factor‐κB (NF‐κB) signaling pathway mediates activation of the
p52/RelB NF‐κB complex and, thereby, regulates specific immunological processes. This …

The NF-κB-inducing kinase (NIK) induces proteolytic processing of NF-κB2/p100 and,
hence, the generation of NF-κB dimers such as p52: RelB but was suggested not to signal …

Processing of the NF-κB2 precursor protein p100 is a major step in noncanonical NF-κB
signaling. This signaling step requires the NF-κB inducing kinase (NIK) and its downstream …

The non-canonical pathway based on processing of NF-κB2 precursor protein p100 to
generate p52 plays a critical role in controlling B cell function and lymphoid organogenesis …

The processing of the nfκb2 gene product p100 to generate p52 is a regulated event, which
is important for the instrumental function of NF-κB. We previously demonstrated that this …

Articles in recent years have described two separate and distinct NF-κB activation pathways
that result in the differential activation of p50-or p52-containing NF-κB complexes. Studies …

(A) Toll-like receptor signaling. A Toll-like receptor (TLR) bound to ligand recruits TIR-
containing adaptor molecules, MyD88 and/or TRIF, which bind to downstream effectors …

NF-κB inducing kinase (NIK) is a kinase that activates the canonical and non-canonical NF-
κB pathways to control transcriptional expression of certain proteins such as cytokines …

While the classical pathway of NF-κB activation plays critical roles in a wide range of
biological processes, the more recently described “non-canonical” NF-κB pathway has …