Summary Inflammatory NF-κB/RelA activation is mediated by the three canonical inhibitors,
IκBα,-β, and-ɛ. We report here the characterization of a fourth inhibitor, nfκb2/p100, that …

NF-κB signaling is required at multiple stages of T cell development and function. The NF-κB
pathway integrates signals from many receptors and involves diverse adapters and kinases …

It has been shown previously that the transcription factor NF-κB and its inhibitor IκBα shuttle
constitutively between cytosol and nucleus. Moreover, we have recently demonstrated …

NF-κ B is an important activator of immune and inflammatory response genes. NF-κ B is
sequestered in the cytoplasm of nonstimulated cells through interaction with the I κ B …

The IκB kinase (IKK)-related kinase NAK (also known as TBK or T2K) contributes to the
activation of NF-κB-dependent gene expression. Here we identify NAP1 (for NAK-associated …

NF-κB is a key transcription factor that dictates the outcome of diverse immune responses.
How NF-κB is regulated by multiple activating receptors that are engaged during natural …

Abstract The NF-κB/REL family of transcription factors pivotally control the inflammatory and
immune responses, as well as other genetic programmes that are central to cell growth and …

The transcription factor nuclear factorkappa B (NF‐KB) is a crucial regulator of many
physiological and patho‐physiological processes, including control of the adaptive and …

The transcription factor NF-κB and associated regulatory factors (including IκB kinase
subunits and the IκB family member Bcl-3) are strongly implicated in a variety of hematologic …

Stimulus-induced nuclear factor-κB (NF-κB) activity, the central mediator of inflammatory
responses and immune function, comprises a family of dimeric transcription factors that …