The functional regeneration of thick vascularized tissues such as bone and muscle is
complicated by the large volume of lost tissue, challenging biomechanical environment, and …

Repair of non-healing bone defects through tissue engineering strategies remains a
challenging feat in the clinic due to the aversive microenvironment surrounding the injured …

Biomaterial based reconstruction is still the most commonly employed method of small bone
defect reconstruction. Bone tissue-engineered techniques are improving, and adjuncts such …

Vascularization remains one of the most important challenges that must be overcome for
tissue engineering to be consistently implemented for reconstruction of large volume bone …

The lack of a functional vascular supply has, to a large extent, hampered the whole range of
clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …

Poor angiogenesis within tissue‐engineered grafts has been identified as a main challenge
limiting the clinical introduction of bone tissue‐engineering (BTE) approaches for the repair …

Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

The prevalent challenge facing tissue engineering today is the lack of adequate
vascularization to support the growth, function, and viability of tissue engineered constructs …

Tissue engineering uses various approaches to restore bone loss and heal critical-size
defects resulting from trauma, infection, tumor resection or other musculoskeletal diseases …

New vascular network formation is a critical step in the wound healing process and a
primary limiting factor in functional tissue regeneration. Like many tissues, neovascular …