Recent research activities have provided new insights in vitamin D metabolism in various
conditions. Furthermore, substantial progress has been made in the analysis of vitamin D …

In recent years it has been shown that vitamin D deficiency is associated with an increased
incidence as well as the progression of a broad range of diseases including osteoporosis …

One hundred years ago, the role of vitamin D for bone mineralization and the prevention of
rickets was discovered. Vitamin D comprises a group of over 50 metabolites with multiple …

Clinical interest in Vitamin D and its purported roles not only in calcium and bone
metabolism but in several other medical conditions (diabetes, cardiovascular disease …

The demand for measurement of vitamin D metabolites for clinical diagnosis and to advance
our understanding of the role of vitamin D in human health has significantly increased in the …

Vitamin D status is typically assessed by the measurement of 25-hydroxy vitamin D (25 (OH)
D). However, in selected patient groups the sole determination of 25 (OH) D has been …

In the past quarter century, more than 50 metabolites of vitamin D have been described. To
date, only a few of these have been quantified in blood, but this has widened our …

Objectives Clinical evaluation of vitamin D status is conventionally performed by measuring
serum levels of a single vitamin D metabolite, 25-hydroxyvitamin D predominantly by …

Vitamin D status is universally assessed by measuring circulating total 25-hydroxyvitamin D
[25 (OH) D] 3, the sum of 25 (OH) D3 and 25 (OH) D2. However, despite the widespread …

Simultaneous and accurate measurement of circulating vitamin D metabolites is critical to
studies of the metabolic regulation of vitamin D and its impact on health and disease. To that …