Objective To establish the evidence of therapeutic hypothermia for newborns with hypoxic
ischemic encephalopathy (HIE). Data Sources Cochrane Central Register of Controlled …

Objectives To systematically review the effectiveness, as determined by survival without
moderate to severe neurodevelopmental disability in infancy and childhood, and the safety …

Context: Therapeutic hypothermia is the recommended treatment for neonates with
moderate or severe hypoxic ischemic encephalopathy (HIE). There is an increasing trend to …

Background The objective of this study was to systematically review randomized trials
assessing therapeutic hypothermia as a treatment for term neonates with hypoxic ischemic …

Importance Hypothermia initiated at less than 6 hours after birth reduces death or disability
for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our …

Background Therapeutic hypothermia reduces the risk of death, or moderate to severe
neurodevelopmental impairment (NDI) in term infants with hypoxic-ischemic …

Hypoxic ischemic encephalopathy (HIE) remains a significant cause of mortality and long-
term disability in late preterm and term infants. Mild therapeutic hypothermia to a rectal …

Objective To evaluate the safety and short-term outcomes of preterm neonates born at 34-35
weeks gestation with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic …

Objective To determine whether moderate hypothermia after hypoxic-ischaemic
encephalopathy in neonates improves survival and neurological outcome at 18 months of …

Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …