Hypoxia–ischemia before or around the time of birth occurs in approximately 2/1000 live
births and is associated with a high risk of death or lifelong disability. Therapeutic …

Background Hypothermia is protective against brain injury after asphyxiation in animal
models. However, the safety and effectiveness of hypothermia in term infants with …

Objective: Therapeutic hypothermia instituted within 6 h of birth has been shown to improve
neurodevelopmental outcomes in term newborns with moderate–to–severe hypoxic …

Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and
disability. Therapeutic hypothermia significantly reduces death and major disability …

Perinatal hypoxic-ischemic encephalopathy (HIE), a subset of neonatal encephalopathy, is
associated with high neonatal mortality and severe long-term neurologic morbidity. Until …

BACKGROUND. Whole-body hypothermia reduced the frequency of death or
moderate/severe disabilities in neonates with hypoxic-ischemic encephalopathy in a …

OBJECTIVES The objectives of this commentary are to review briefly the background and
current knowledge regarding the therapeutic efficacy and safety of sustained mild to …

Objectives. To determine the neurodevelopmental outcome of infants treated with head
cooling with systemic hypothermia after hypoxic-ischemic encephalopathy. Study Group …

Hypoxic-ischemic injury may cause multisystem organ damage with significant aberrations
in clotting, renal, and cardiac functions. Systemic hypothermia may aggravate these medical …

Background Whether hypothermic therapy improves neurodevelopmental outcomes in
newborn infants with asphyxial encephalopathy is uncertain. Methods We performed a …