Introduction CXCL12-CXCR4 signaling has been shown to play a role in breast cancer
progression by enhancing tumor growth, angiogenesis, triggering cancer cell invasion in …

CXCR4 and its ligand CXCL12 can promote the proliferation, survival, and invasion of
cancer cells. They have been shown to play an important role in regulating metastasis of …

Introduction Although CXC motif chemokine 12 (CXCL12) has been shown to bind to CXC
chemokine receptor type 7 (CXCR7), the exact molecular mechanism regulations by …

Abstract Introduction Neu (HER2/ErbB2) is overexpressed in 25% to 30% of human breast
cancer, correlating with a poor prognosis. Researchers in previous studies who used the …

Aberrant expression of CXCR4 in human breast cancer correlates with metastasis to tissues
secreting CXCL12. To understand the mechanism by which CXCR4 mediates breast cancer …

Chemokines are 8–12 kDa peptides that function as chemoattractant cytokines and are
involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G …

Background A growing body of work implicates chemokines, in particular CXCL12 and its
receptors, in the progression and site-specific metastasis of various cancers, including …

Breast cancer is one of the leading causes of cancer related deaths worldwide. Breast
cancer-related mortality is associated with the development of metastatic potential of primary …

There is growing evidence that several chemokine receptors including CXCR3 contribute to
metastasis of breast and other cancers, however, in order to target CXCR3 effectively, it is …

The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …