Genomic basis for natural product biosynthetic diversity in the actinomycetes
M Nett, H Ikeda, BS Moore - Natural product reports, 2009 - pubs.rsc.org
Covering: up to mid-2009 The phylum Actinobacteria hosts diverse high G+ C, Gram-
positive bacteria that have evolved a complex chemical language of natural product …
positive bacteria that have evolved a complex chemical language of natural product …
[HTML][HTML] Concepts and methods to access novel antibiotics from actinomycetes
Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
Natural product discovery: past, present, and future
L Katz, RH Baltz - Journal of Industrial Microbiology and …, 2016 - academic.oup.com
Microorganisms have provided abundant sources of natural products which have been
developed as commercial products for human medicine, animal health, and plant crop …
developed as commercial products for human medicine, animal health, and plant crop …
Ecology and genomics of Actinobacteria: new concepts for natural product discovery
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …
Production of specialized metabolites by Streptomyces coelicolor A3 (2)
G Van Keulen, PJ Dyson - Advances in applied microbiology, 2014 - Elsevier
The actinomycetes are well-known bioactive natural product producers, comprising the
Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic …
Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic …
Phylogenomic analysis of natural products biosynthetic gene clusters allows discovery of arseno-organic metabolites in model streptomycetes
P Cruz-Morales, JF Kopp… - Genome biology and …, 2016 - academic.oup.com
Natural products from microbes have provided humans with beneficial antibiotics for
millennia. However, a decline in the pace of antibiotic discovery exerts pressure on human …
millennia. However, a decline in the pace of antibiotic discovery exerts pressure on human …
[HTML][HTML] Actinomycetes: The antibiotics producers
Y Mast, E Stegmann - Antibiotics, 2019 - mdpi.com
Actinomycetes are well known as an inexhaustible source for antibiotics. Most of the known
antimicrobials today were originally isolated from actinomycetes, especially from the genus …
antimicrobials today were originally isolated from actinomycetes, especially from the genus …
Cryptic or silent? The known unknowns, unknown knowns, and unknown unknowns of secondary metabolism
PA Hoskisson, RF Seipke - MBio, 2020 - Am Soc Microbiol
Microbial natural products, particularly those produced by filamentous Actinobacteria,
underpin the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic …
underpin the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic …
[HTML][HTML] Elicitation of secondary metabolism in actinomycetes
UR Abdelmohsen, T Grkovic, S Balasubramanian… - Biotechnology …, 2015 - Elsevier
Genomic sequence data have revealed the presence of a large fraction of putatively silent
biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary …
biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary …
Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities
RH Baltz - Journal of Industrial Microbiology and Biotechnology, 2019 - academic.oup.com
Natural product discovery from microorganisms provided important sources for antibiotics,
anti-cancer agents, immune-modulators, anthelminthic agents, and insecticides during a …
anti-cancer agents, immune-modulators, anthelminthic agents, and insecticides during a …