Crosstalk of reactive oxygen species and NF-κB signaling

MJ Morgan, Z Liu - Cell research, 2011 - nature.com
NF-κB targets and various ways in which ROS have been proposed to impact NF-κB signaling
pathways. … In summary, ROS interacts with NF-κB signaling pathways in many ways. The …

NF-κB signaling pathway as a target for human tumor radiosensitization

M Jung, A Dritschilo - Seminars in radiation oncology, 2001 - Elsevier
… Therefore, we hypothesize that the signaling pathway involving ATM/NF-KB/IKB offers
attractive potential molecular targets for radiation sensitization in strategies to enhance the …

NF-κB signaling: multiple angles to target OA

KB Marcu, M Otero, E Olivotto, R Maria Borzi… - Current drug …, 2010 - ingentaconnect.com
… We suggest that the NF-B signaling pathways provide multiple avenues for targeting OA,
because of their contributions not only to pro-inflammatory, stress-related responses, but also …

[HTML][HTML] The complex interplay between autophagy and NF-κB signaling pathways in cancer cells

A Trocoli, M Djavaheri-Mergny - American journal of cancer …, 2011 - ncbi.nlm.nih.gov
… the NF-κB signaling pathways. Autophagy may constitute a pathway through which NF-κB
signaling … either in the termination of the initial NF-κB activation or conversely in the persistent …

Advancement of NF-κB signaling pathway: a novel target in pancreatic cancer

KC Pramanik, MR Makena, K Bhowmick… - International journal of …, 2018 - mdpi.com
… involvement of NF-κB in PADC’s progression and resistance. We also highlighted the
interaction of NF-κB with other signaling pathways. Lastly, we also aim to discuss how NF-κB could …

A fourth IκB protein within the NF-κB signaling module

S Basak, H Kim, JD Kearns, V Tergaonkar, E O'Dea… - Cell, 2007 - cell.com
… In contrast, a second NF-κB activation pathway is thought to regulate the activity of NF-κB/RelB
dimers via a precursor processing mechanism. This signaling pathway is activated in …

Transcriptional regulation via the NF-κB signaling module

A Hoffmann, G Natoli, G Ghosh - Oncogene, 2006 - nature.com
… Transcriptional specificity is achieved via combinatorial control of signaling pathways: NF-κB
activity does not function alone, but in conjunction with several other transcription factors …

Potential pharmacological control of the NF-κB pathway

G Sethi, V Tergaonkar - Trends in pharmacological sciences, 2009 - cell.com
… activation but this is a rather non-specific mechanism of blocking NF-κB because these
molecules contribute to many signaling pathways. Indeed, wortmannin and other …

The NF-κB signaling pathway, the microbiota, and gastrointestinal tumorigenesis: recent advances

C Peng, Y Ouyang, N Lu, N Li - Frontiers in Immunology, 2020 - frontiersin.org
NF-κB plays a crucial role in the host response to microbial infection through orchestrating
innate and adaptive immune functions. Moreover, NF-κB … of the NF-κB signaling pathway by …

The IκB kinase complex: master regulator of NF-κB signaling

LA Solt, MJ May - Immunologic research, 2008 - Springer
… The NF-κB Signaling Pathway: This model depicts the major components of the classical
NF-κB pathway. Engagement of a receptor by its ligand (eg, TNF binding to TNFR) induces the …