… up-regulation of PD-L1 by oncogenic activation of EGFR in NSCLC [53]. Whether other growth
factors drive PD-L1 … factor has been shown to up-regulate PD-L1 in a mouse melanoma …

… homolog 2 negatively regulated PD-L1 expression by … regulated PD-L1 expression [30].
Inhibiting methylation of DNA by DNA methyltransferase inhibitors (DNMTis) increased PD-L1 …

… TNF-α may synergistically induce PD-L1 expression in human … PD-L1 mRNA expression,
but up-regulated PD-L1 protein expression in HCT116 and LNCaP cells. TNF-α induced PD-L1 …

… of PD-L1 was suppressed by knocking down LMP1 in EBV positive cell lines. We further
demonstrated that LMP1 up-regulated PD-L1 … with LMP1 in up-regulating PD-L1 in NPC. …

… several cytokines regulating PD-L1 expression. Two … PD-L1 up-regulation. Blue arrows
indicate activation of NF-kB pathway; black arrows indicate NF-κB-mediated PD-L1 up-regulation…

… PD-L1 upregulation, we sought to determine whether the JAK/STAT pathway regulates PD-L1
… , and JAK2 inhibitor AG490 reversed the upregulation of PD-L1 induced by the anticancer …

… Here, we find that Th1 and Th2 cells can differentially up-regulate PD-L1 and PD-L2 on
macrophages in the periphery; hence, they are the major determinant of the costimulatory …

Background/Aim: The programmed death 1 (PD-1) receptor and its ligand (PD-L1) play pivotal
roles in regulating host immune responses. However, the inhibitory effects of this pathway …

… in PD-L1. mTOR may not be significantly involved in the regulation of PD-L1, whereas PI3-K
pathway played differential roles on PD-L1 mRNA and cell-surface PD-L1 expression, in the …

… ROS regulate PD-L1 expression and secretion of immunosuppressive cytokines in BMDMs.
(A) Pdl1 … Thus, we hypothesized that ROS might regulate PD-L1 expression through NF-κB …