… Understanding how TME-resident cytokines and signaling pathways regulate PD-L1
expression may provide therapeutic opportunities to mitigate PD-L1-induced intratumoral …

… regulate PD-L1 expression in AML cells We hypothesized that MUC1 regulation of PD-L1
may be mediated by noncoding RNAs, which are known to epigenetically regulate cellular …

… our understanding on PD-L1/PD-1 axis in PC is still quite limited. In this study, we showed
for the first time that lncRNA KCNQ1OT1 sponged miR-15a to up-regulate PD-L1 expression, …

… Therefore, it is very urgent to study the potential effect factors that regulate PD-L1. PD-L1
can cause T cell dysfunction and failure, prevents cytotoxic T cells from effectively targeting …

… that regulate the expression of PD-L1 remain unclear. A study found that PD-L1 expression
… PD-L1 by IFN-γ requires mitogen-activated protein kinases (MAPK). Our results showed that …

… However, the effect of PD-1/PD-L1 on hepatic … up-regulation of PD-1 and PD-L1 in liver
biopsies from 32 chronic HBV patients compared to 4 healthy donors. PD-1/PD-L1 up-regulation …

… in the process of anti-PD-1/PD-L1 immunotherapy. Tumor-associated macrophages (TAMs)
play key roles in regulating PD-1/PD-L1 immunosuppression by inhibiting the recruitment …

… Taken together, our study suggested that upregulation of circulating PD-1/PD-L1 could
serve as novel valid immunological markers in predicting disease progression of HCC patients …

… We found that PD-L1 upregulation mainly inhibited proliferation rather than promoted apoptosis
of T … The result suggested upregulation of PD-L1 is able to induce the immune suppress, …

… underlying PARPi-enhanced PD-L1 protein expression. … to regulate PD-L1 expression level
(19, 22, 23). In an attempt to identify the potential signaling pathways that regulate PD-L1, we …