… It was demonstrated that the TM fraction and PDG induced up‐regulation of PD‐L1 … in
PD‐L1 up‐regulation in colon cancer cells. In addition, the mechanism of PD‐L1 up‐regulation …

… Here, we show that PD-L1 + melanomas overexpress PD-1, LAG-3, … PD-L1 on myeloid
cells but not tumor cells, and thus begins to elucidate novel mechanisms for PD-L1 upregulation …

… controlling PD-L1 expression. In this review, we focus on the regulation of PD-L1 expression
in … carcinoma (SCC), and we discuss intrinsic and extrinsic regulation of PD-L1 expression. …

… PD-L1 up-regulation is markedly enhanced in STAT3 LOF and STAT1 GOF lymphocytes
compared with healthy donor cells. Both STAT1 hyperphosphorylation and PD-L1 up-regulation …

… as driving PD-L1 expression. … regulate PD-L1 transcription by directly binding to the PD-L1
promoter. Overexpressed MYC, HIF-1α and HIF-2α come into play for PD-L1 upregulation in …

… Although a role of IRF1 in mediating the PD-L1 regulation by IRF2 was not demonstrated
in this report (30), this observation again points toward a role of IRF1 in PD-L1 induction and …

… -chronic inflammation might activate the DSB/IRF-1 signalling axis, which might serve as
the primary regulatory mechanism for regulating PD-L1 expression in UC carcinogenesis. …

… Moreover, chromatin immunoprecipitation revealed direct binding of STAT-3 to the PD-L1
promoter. Those findings indicate a pivotal role of STAT-3 in regulating PD-L1 expression. …

… thus are unlikely to be involved in the regulation of PD-L1 in our model system. IL-10 signaling
through STAT3 has been shown to up-regulate PD-L1 protein in dendritic cells 55,56 , but …

… death-1 (PD-1). We detected high amounts of soluble PD-L1 (sPD-L1) and soluble PD-L2
(… In addition, we observed hantavirus-induced PD-L1 upregulation in mice with a humanized …