Outcomes in chemotherapy-ineligible elderly patients with newly diagnosed acute myeloid leukemia treated with venetoclax plus azacitidine: A pooled analysis

A Venditti, JZ Hou, P Fenaux, BA Jonas, R Vrhovac… - Blood, 2023 - Elsevier
Introduction: Elderly patients (aged≥ 75 years), with newly diagnosed acute myeloid
leukemia (ND AML) frequently are ineligible to receive intensive chemotherapy (IC) and …

Acute myeloid leukemia in the elderly: what constitutes treatment value?

C Nabhan, S Kamat, J Karl Kish - Leukemia & Lymphoma, 2019 - Taylor & Francis
Abstract Treatment options for patients with acute myeloid leukemia (AML), who are unfit for
induction chemotherapy are unsatisfactory. Overall survival (OS) superiority has not been …

Early mortality and survival in older adults with acute myeloid leukemia

M Pant, VR Bhatt - International journal of hematologic oncology, 2017 - Taylor & Francis
Acute myeloid leukemia (AML) is a disease of older adults [1] and has a median age of 68
years at the time of diagnosis. The management of AML in older patients (> 60 years) is far …

Pretreatment evaluation and prognosis of acute myeloid leukemia in older adults

RA Larson, HD Klepin - 2013 - uptodate.com
Prognosis for older patients with acute myeloid leukemia (AML) is generally inferior to that in
younger patients. However, there is no consensus definition of" older adult" regarding …

Real world data on unique challenges and outcomes of older patients with AML from resource limited settings: Indian Acute Leukemia Research Database (INwARD) …

S Singh, S Lionel, H Jain, L Nayak, S Selvarajan… - Blood, 2022 - ashpublications.org
Despite significant advances in the treatment of acute myeloid leukemia (AML), outcomes in
older patients continue to be suboptimal, due to a combination of adverse disease …

Real World Effectiveness of 7+ 3 Intensive Chemotherapy Vs Venetoclax and Hypomethylating Agent for Initial Therapy in Adult Acute Myeloid Leukemia

A Matthews, AE Perl, SM Luger, S Gill, C Lai, DL Porter… - Blood, 2022 - ashpublications.org
Introduction Initial treatment selection for older adults with AML remains challenging.
Historically, clinicians and patients had to choose between intensive chemotherapy (7+ 3) …

Advances in the treatment of elderly and frail patients with acute myeloid leukemia

S Amadori, MI Del Principe… - Current Opinion in …, 2014 - journals.lww.com
Advances in the treatment of elderly and frail patients with... : Current Opinion in Oncology
Advances in the treatment of elderly and frail patients with acute myeloid leukemia : Current …

[HTML][HTML] Effectiveness and safety of therapeutic regimens for elderly patients with acute myeloid leukemia: a systematic literature review

JA Bell, A Galaznik, R Huelin, M Stokes, Y Guo… - … Myeloma and Leukemia, 2018 - Elsevier
Acute myeloid leukemia (AML) is the second most common leukemia among adults.
Although the median age at diagnosis is 67 years, with approximately one third of patients …

Survival, response rates, and post-transplant outcomes in patients with acute myeloid leukemia aged 60-75 treated with high intensity chemotherapy vs. lower …

K Sahasrabudhe, Y Huang, M Rebechi, P Elder… - Frontiers in …, 2022 - frontiersin.org
The United States Food and Drug Administration has approved several oral, targeted
therapies for the treatment of Acute Myeloid Leukemia (AML) in recent years. These agents …

Survival Outcomes and Health-Related Quality of Life in Older Adults Diagnosed with Acute Myeloid Leukemia Receiving Frontline Therapy in Daily Practice

F Ramos, ML Hermosín, M Fuertes-Núñez… - Journal of personalized …, 2023 - mdpi.com
Acute myeloid leukemia has a poor prognosis in older adults, and its management is often
unclear due to its underrepresentation in clinical trials. Both overall survival (OS) and health …